Genetics of Fibromyalgia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00071162|
Recruitment Status : Unknown
Verified March 2009 by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Recruitment status was: Active, not recruiting
First Posted : October 15, 2003
Last Update Posted : April 1, 2009
|Condition or disease|
|Fibromyalgia Irritable Bowel Syndrome Chronic Fatigue Syndrome Depression|
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.
Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
|Study Type :||Observational|
|Actual Enrollment :||560 participants|
|Official Title:||Fibromyalgia Family Study Registry|
|Study Start Date :||September 1999|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00071162
|United States, Illinois|
|University of Illinois at Peoria|
|Peoria, Illinois, United States, 60612|
|United States, Ohio|
|University of Cincinnati|
|Cincinnati, Ohio, United States, 45221|
|Case Western Reserve University|
|Cleveland, Ohio, United States, 44109|
|United States, Texas|
|University of Texas Health Sciences Center|
|San Antonio, Texas, United States, 78229|
|Study Chair:||Sudha Iyengar, PhD||Case Western Reserve University|