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Enhancing the Outcome of Skills Training for People With Schizophrenia

This study has been completed.
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
New York State Psychiatric Institute Identifier:
First received: September 24, 2003
Last updated: September 23, 2013
Last verified: September 2013
This study will determine the effectiveness of skills training in people with schizophrenia and the applicability of the acquired skills in the "real world."

Condition Intervention
Schizophrenia Procedure: Social skills and symptom management training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Skills Training for Schizophrenia: Enhancing Outcomes

Resource links provided by NLM:

Further study details as provided by New York State Psychiatric Institute:

Estimated Enrollment: 60
Study Start Date: April 2001
Study Completion Date: November 2005
Primary Completion Date: November 2005 (Final data collection date for primary outcome measure)
Detailed Description:

People with schizophrenia have a large number of social and symptom management training programs available to them. Studies suggest that these training programs are effective, but their generalizability and effectiveness in outpatient settings has not been thoroughly examined. This study will examine the treatment outcomes of a skills training approach in schizophrenic individuals taking antipsychotic medication.

Participants taking stable doses of risperidone, olanzapine, or quetiapine will be randomly assigned to receive either intensive symptom management and social skills training or group therapy for 12 months. A verbal memory test will be used to stratify the randomization procedure and to control for neurocognitive functioning.


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of schizophrenia or schizoaffective disorder for > 5 years
  • Use of stable dose risperidone, olanzapine, or quetiapine for at least 1 month with no planned medication changes
  • Social Behavior Scale (SBS) score > 45
  • Willing and able to provide informed consent

Exclusion Criteria:

  • Intelligence Quotient < 70
  • Use of more than one antipsychotic medication
  • Use of benzodiazepines, tricyclic antidepressants, or anticholinergic medication commonly used to treat extrapyramidal symptoms
  • Diagnostic and Statistical Manual (DSM)-IV criteria for alcohol or other substance dependence
  • History of any traumatic brain injury leading to loss of consciousness for > 30 minutes
  • Diagnosis of a comorbid medical condition that could interfere with antipsychotic medication treatment or the ability to complete the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00069433

United States, Connecticut
Hall-Brooke-The Center
Bridgeport, Connecticut, United States, 06606
Hall-Brooke Behavioral Health Services
Westport, Connecticut, United States, 06880
Sponsors and Collaborators
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)
  More Information

Responsible Party: New York State Psychiatric Institute Identifier: NCT00069433     History of Changes
Other Study ID Numbers: #4339
R01MH066362 ( U.S. NIH Grant/Contract )
Study First Received: September 24, 2003
Last Updated: September 23, 2013

Keywords provided by New York State Psychiatric Institute:
Psychotic Disorders

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on September 25, 2017