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Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00068497
Recruitment Status : Completed
First Posted : September 11, 2003
Last Update Posted : January 14, 2013
Sponsor:
Information provided by (Responsible Party):
National Cancer Institute (NCI)

Study Description
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Brief Summary:
This phase I trial is studying the side effects of gefitinib in treating patients with metastatic or unresectable head and neck cancer or non-small cell lung cancer. Gefitinib may stop the growth of cancer cells by blocking the enzymes necessary for their growth

Condition or disease Intervention/treatment Phase
Anaplastic Thyroid Cancer Insular Thyroid Cancer Metastatic Parathyroid Cancer Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Basal Cell Carcinoma of the Lip Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity Recurrent Lymphoepithelioma of the Nasopharynx Recurrent Lymphoepithelioma of the Oropharynx Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Non-small Cell Lung Cancer Recurrent Parathyroid Cancer Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Thyroid Cancer Recurrent Verrucous Carcinoma of the Larynx Stage III Follicular Thyroid Cancer Stage III Papillary Thyroid Cancer Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Verrucous Carcinoma of the Larynx Stage IIIB Non-small Cell Lung Cancer Stage IV Lymphoepithelioma of the Nasopharynx Stage IV Non-small Cell Lung Cancer Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity Stage IVA Basal Cell Carcinoma of the Lip Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity Stage IVA Follicular Thyroid Cancer Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity Stage IVA Lymphoepithelioma of the Oropharynx Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity Stage IVA Papillary Thyroid Cancer Stage IVA Salivary Gland Cancer Stage IVA Squamous Cell Carcinoma of the Larynx Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVA Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVA Verrucous Carcinoma of the Larynx Stage IVA Verrucous Carcinoma of the Oral Cavity Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity Stage IVB Basal Cell Carcinoma of the Lip Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity Stage IVB Follicular Thyroid Cancer Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity Stage IVB Lymphoepithelioma of the Oropharynx Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity Stage IVB Papillary Thyroid Cancer Stage IVB Salivary Gland Cancer Stage IVB Squamous Cell Carcinoma of the Larynx Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVB Squamous Cell Carcinoma of the Oropharynx Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVB Verrucous Carcinoma of the Larynx Stage IVB Verrucous Carcinoma of the Oral Cavity Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity Stage IVC Basal Cell Carcinoma of the Lip Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity Stage IVC Follicular Thyroid Cancer Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity Stage IVC Lymphoepithelioma of the Oropharynx Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity Stage IVC Papillary Thyroid Cancer Stage IVC Salivary Gland Cancer Stage IVC Squamous Cell Carcinoma of the Larynx Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVC Squamous Cell Carcinoma of the Oropharynx Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVC Verrucous Carcinoma of the Larynx Stage IVC Verrucous Carcinoma of the Oral Cavity Thryoid Gland Nonmedullary Carcinoma Thyroid Gland Medullary Carcinoma Tongue Cancer Untreated Metastatic Squamous Neck Cancer With Occult Primary Drug: gefitinib Not Applicable

Detailed Description:

PRIMARY OBJECTIVES:

I. To assess the feasibility of enrolling patients ages 75 years or older and 50 years and younger with metastatic or unresectable head and neck cancer or non-small cell lung cancer, to a structured pilot study that includes pharmacokinetic sampling in a special patient population.

II. To preliminarily compare the ZD-1839 peak concentration level, elimination half-life and steady state level between the two patient age groups.

OUTLINE: This is a pilot, multicenter study. Patients are stratified according to age (75 years and over vs 50 years and under)

Patients receive oral gefitinib on day 1 and then daily beginning on day 8. Treatment continues in the absence of disease progression or unacceptable toxicity.

Patients are followed for 30 days and then for up to 3 years after study registration.

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Single Agent ZD-1839 (NSC-715055, IND-61187) in Patients With Advanced Head and Neck Carcinoma or Non-Small Cell Lung Cancer Aged 75 Years and Older (and in a Cohort of Patients 50 Years Old and Younger)
Study Start Date : August 2003
Actual Primary Completion Date : December 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Cancer
Drug Information available for: Gefitinib

Arms and Interventions
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Arm Intervention/treatment
Experimental: Treatment (gefitinib)
Patients receive oral gefitinib on day 1 and then daily beginning on day 8. Treatment continues in the absence of disease progression or unacceptable toxicity.
 Drug: gefitinib
Given orally
Other Names:
  • Iressa
  • ZD 1839


Outcome Measures
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Primary Outcome Measures :
  1. Feasibility of enrolling patients aged 75 or older and 50 or younger to the study setting [ Time Frame: 1 year ]
  2. Peak ZD1839 concentration level [ Time Frame: Up to 3 years ]
  3. Elimination half-life [ Time Frame: Up to 3 years ]
  4. Toxicity rates between the two age groups by CTCAE version 3.0 [ Time Frame: Up to 3 years ]
  5. Responses observed [ Time Frame: Up to 3 years ]
    Will be reported separately for the two tumor types, i.e., head and neck vs. lung cancer, with 95% confidence intervals for the estimated response rates.

  6. Survival for each tumor type [ Time Frame: Up to 3 years ]
    Kaplan-Meier curves will summarize with median estimates and associated 95% confidence intervals.


Eligibility Criteria
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Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients must have histologically or cytologically confirmed head and neck carcinoma or non-small cell lung cancer which is metastatic or unresectable for which standard curative or palliative measures do not exist or are no longer effective or are likely to be as effective as ZD1839; patients with known brain metastases are only eligible if their brain metastases have been treated and if in the opinion of the treating physician they are stable
  • Patients must be 75 years or older, or 50 years of age or younger
  • Serum creatinine =< the institutional upper limit of normal
  • Bilirubin =< the institutional upper limit of normal
  • SGOT or SGPT =< 2.5 x the institutional upper limit of normal; SGOT and SGPT could be =< 5 x the upper limit of normal if the patient has liver metastases as long as the bilirubin is normal
  • AGC of >= 1,500/ul
  • Platelet count of >= 100,000/ul
  • Patients requiring agents that induce CYP3A4 are excluded from the study, at the present time, agents known to induce CYP3A4 include the antibiotics nafcillin and rifampin, the anticonvulsants carbamazepine, phenobarbital, phenytoin, oxcarbazepine, fosphenytoin and primidone as well as St. John's Wort, rifabutin, rifapentine and modafinil
  • Patients may or may not have received prior chemotherapy; patients must not have a curative option and in the opinion of the treating physician there is no other treatment option likely to provide greater benefit; patients must not have received prior treatment with EGFR inhibitors; patients must have recovered from the effects of prior therapy; all prior therapies must be documented
  • Patients must have a performance status of 0-2 by Zubrod standards
  • Patients must not be planning to receive concurrent radiation therapy, hormone therapy, chemotherapy or immune therapy for malignancy while receiving protocol treatment
  • Patients must agree to undergo pharmacokinetic sampling and sample submission
  • Patients known to be HIV positive and receiving retroviral therapies are not eligible
  • Patients with any evidence of severe or uncontrolled systemic disease (e.g., unstable or uncompensated respiratory, cardiac or infection) are not eligible
  • Patients must be able to swallow oral medication in pill form; patients may not receive study medication through a feeding tube
  • A baseline slit lamp examination is NOT required; however, patients with eye symptoms (eye pain, tearing, redness, vision problems) or known eye disorders should be evaluated by an ophthalmologist/optometrist prior to registration and the results documented on the toxicity form in the notes section
  • Patients must not be pregnant or nursing; patients of reproductive potential must have agreed to use an effective contraceptive method
  • If day 28 or 42 falls on a weekend or holiday, the limit may be extended to the next working day
  • In calculating days of tests and measurements, the day a test or measurement is done is considered day 0; therefore, if a test is done on a Monday, the Monday four weeks later would be considered day 28; this allows for efficient patient scheduling without exceeding guidelines
  • All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
  • At the time of patient registration, the treating institution's name and ID number must be provided to the Data Operations Center in Seattle in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered into the data base
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00068497


Locations
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United States, Texas
Southwest Oncology Group
San Antonio, Texas, United States, 78245
Sponsors and Collaborators
National Cancer Institute (NCI)
Investigators
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Principal Investigator: Shirish Gadgeel Southwest Oncology Group
More Information
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Responsible Party: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00068497    
Other Study ID Numbers: NCI-2012-03171
S0322
U10CA032102 ( U.S. NIH Grant/Contract )
CDR0000322890 ( Registry Identifier: PDQ (Physician Data Query) )
First Posted: September 11, 2003    Key Record Dates
Last Update Posted: January 14, 2013
Last Verified: January 2013
Additional relevant MeSH terms:
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Carcinoma
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Thyroid Neoplasms
Laryngeal Neoplasms
Carcinoma, Basal Cell
Oropharyngeal Neoplasms
Carcinoma, Verrucous
Squamous Cell Carcinoma of Head and Neck
Papilloma
Salivary Gland Neoplasms
Nasopharyngeal Carcinoma
Paranasal Sinus Neoplasms
 Carcinoma, Adenoid Cystic
Neoplasms, Unknown Primary
Carcinoma, Mucoepidermoid
Mucoepidermoid Tumor
Esthesioneuroblastoma, Olfactory
Papilloma, Inverted
Thyroid Cancer, Papillary
Thyroid Carcinoma, Anaplastic
Tongue Neoplasms
Carcinoma, Medullary
Adenocarcinoma, Follicular
Parathyroid Neoplasms
Laryngeal Diseases
Granuloma
Thyroid Diseases