Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy
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| ClinicalTrials.gov Identifier: NCT00066170 |
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Recruitment Status :
Completed
First Posted : August 6, 2003
Results First Posted : November 30, 2011
Last Update Posted : December 29, 2011
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Sponsor:
Jazz Pharmaceuticals
Information provided by:
Jazz Pharmaceuticals
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Brief Summary:
This study will be conducted as a randomized, double blind, double-dummy, placebo-controlled, parallel-group trial in patients diagnosed with narcolepsy. Volunteers for this trial will be required to make 5 visits over up to 14 weeks to a participating expert physician practitioner for various sleep and narcolepsy evaluations and diaries will also be collected. Participants will take assigned medications during the course of the trial. Subjects will have a 25% probability of receiving placebo for both drugs (modafinil and Xyrem). All subject volunteers must meet criteria for narcolepsy and have evidence of daytime sleepiness. Patients will not incur any personal medical expenses due to participation in this trial. The sponsor is covering all visit costs not covered by insurance and there are some funds for patient expenses such as travel.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Narcolepsy | Drug: Xyrem Drug: Xyrem Placebo Drug: Modafinil at established dose Drug: Modafinil (Placebo) | Phase 3 |
| Study Type : | Interventional (Clinical Trial) |
| Actual Enrollment : | 231 participants |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | Triple (Participant, Care Provider, Investigator) |
| Primary Purpose: | Treatment |
| Official Title: | Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Parallel-Group, Multi-Center Trial Comparing the Effects of Orally Administered Xyrem (Sodium Oxybate) and Modafinil With Placebo in Treatment of Daytime Sleepiness in Narcolepsy |
| Study Start Date : | April 2003 |
| Actual Primary Completion Date : | July 2004 |
| Actual Study Completion Date : | November 2004 |
Resource links provided by the National Library of Medicine
MedlinePlus Genetics related topics:
Narcolepsy
MedlinePlus related topics:
Club Drugs
| Arm | Intervention/treatment |
|---|---|
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Experimental: Group 1.
Xyrem + Modafinil Placebo
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Drug: Xyrem
Xyrem oral solution at 6 g/day for 4 weeks and 9 g/day for another 4 weeks.
Other Name: Sodium Oxybate Drug: Modafinil (Placebo) Modafinil Placebo oral capsules 1 to 3 capsules per day for 8 weeks.
Other Name: Provigil Placebo |
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Placebo Comparator: Group 2:
Xyrem Placebo + Modafinil Placebo
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Drug: Xyrem Placebo
Xyrem Placebo oral solution 12 ml per day for 4 weeks and 18 ml per day for another 4 weeks.
Other Name: Sodium Oxybate Placebo Drug: Modafinil (Placebo) Modafinil Placebo oral capsules 1 to 3 capsules per day for 8 weeks.
Other Name: Provigil Placebo |
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Active Comparator: Group 3
Xyrem Placebo + Modafinil at established dose
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Drug: Xyrem Placebo
Xyrem Placebo oral solution 12 ml per day for 4 weeks and 18 ml per day for another 4 weeks.
Other Name: Sodium Oxybate Placebo Drug: Modafinil at established dose Modafinil oral capsules at 200 to 600 mg per day for 8 weeks.
Other Name: Provigil |
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Experimental: Group 4:
Xyrem + Modafinil at established dose
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Drug: Xyrem
Xyrem oral solution at 6 g/day for 4 weeks and 9 g/day for another 4 weeks.
Other Name: Sodium Oxybate Drug: Modafinil at established dose Modafinil oral capsules at 200 to 600 mg per day for 8 weeks.
Other Name: Provigil |
Primary Outcome Measures :
- Daytime Sleep Latency as Measured by the Maintenance of Wakefulness Test (MWT) [ Time Frame: Baseline to Week 8 ]The Maintenance of Wakefulness Test consisted of four 20 minute tests of the patient's ability to remain awake in soporific conditions. The Mean change from baseline to week 8 in the average MWT number of minutes until sleep onset was the primary endpoint.
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| Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
INCLUSION CRITERIA
Patients will be included in the trial if they:
- Have signed and dated an informed consent prior to beginning protocol required procedures.
- Are willing and able to complete the entire trial as described in the protocol.
- Are 18 years of age or older.
- Fulfill the International Classification of Sleep Disorders criteria for the diagnosis of narcolepsy.
- Are taking stable doses of modafinil (200 to 600 mg/day) for the treatment of daytime sleepiness for a period of three months or greater and the modafinil dose has been stable for at least 1 month prior to entering this trial
- Females may be included who are surgically sterile, two years post-menopausal, or if of child-bearing potential, using a medically accepted method of birth control (e.g., barrier method with spermicide, oral contraceptive, or abstinence) and agree to continue use of this method for the duration of the trial.
- In the opinion of the investigator have adequate support for the duration of the trial to include transportation to and from the trial site. In addition, if in the investigator's assessment it is clinically indicated, the patient is willing to not operate a car or heavy machinery for the duration of the trial or for as long as the investigator deems clinically indicated.
EXCLUSION CRITERIA
Patients will be excluded from the trial if they:
- Have received gamma-hydroxybutyrate in the last 30 days.
- Have taken any investigational therapy within the 30-day period prior to the initial screening visit (Visit 1) for this trial.
- Have sleep apnea syndrome, defined as an Apnea Index > 10 per hour or an AHI (Apnea Hypopnea Index) greater than 15 per hour, or have any other cause of daytime sleepiness, and have any other disorder(s) that can be considered a primary cause of excessive daytime sleepiness (e.g., severe periodic leg movement syndrome as determined by the investigator, sleep apnea, sleep deprivation).
- Are taking hypnotics, tranquilizers, antihistamines (except for non-sedating antihistamines), benzodiazepines or clonidine at the start of the baseline period. Patients taking anticonvulsants are not eligible to participate event if they are willing to washout anticonvulsants for the trial.
- Are experiencing any major illness, including unstable cardiovascular, endocrine, neoplastic, gastrointestinal, hematologic, hepatic, immunologic, metabolic, neurological (other than narcolepsy/cataplexy), pulmonary, and/or renal disease which would place the patient at risk during the trial or compromise the objectives outlined in the protocol.
- Have psychiatric disorders, major affective or psychotic disorders, or other problems that, in the investigator's opinion, would preclude the patient's participation and completion of this trial or compromise reliable representation of subjective symptoms.
- Have a current or recent (within one year) history of a substance use disorder including alcohol abuse as defined by the DSM-IV.
- Have a serum creatinine greater than 2.0 mg/dL, abnormal liver function tests (SGOT [AST] or SGPT [ALT] more than twice the upper limit of normal), or elevated serum bilirubin (more than 1.5 times the upper limit of normal), or pre-trial ECG results demonstrating clinically significant arrhythmias, greater than a first degree AV block or a history of myocardial infarction within the last six months.
- Have an occupation that requires variable shift work or routine night shift.
- Have a clinically significant history of seizure disorder either past or present, a history of clinically significant head trauma (i.e., concussion resulting in clinically significant loss of consciousness) or past invasive intracranial surgery, and are taking anticonvulsant medications.
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00066170
Locations
Show 40 study locations
Sponsors and Collaborators
Jazz Pharmaceuticals
Investigators
| Study Director: | Yanping Zheng, MD | Jazz Pharmaceuticals, Inc |
Additional Information:
Publications of Results:
Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Publications of Results:
Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Senior Director Clinical Development, Jazz Pharmaceuticals, Inc. |
| ClinicalTrials.gov Identifier: | NCT00066170 |
| Other Study ID Numbers: |
OMC-SXB-22 |
| First Posted: | August 6, 2003 Key Record Dates |
| Results First Posted: | November 30, 2011 |
| Last Update Posted: | December 29, 2011 |
| Last Verified: | December 2011 |
Keywords provided by Jazz Pharmaceuticals:
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Narcolepsy Daytime Sleepiness Daytime sleepiness in narcolepsy |
Additional relevant MeSH terms:
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Narcolepsy Disorders of Excessive Somnolence Sleepiness Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases Mental Disorders Sodium Oxybate Modafinil Central Nervous System Stimulants |
Physiological Effects of Drugs Wakefulness-Promoting Agents Cytochrome P-450 CYP3A Inducers Cytochrome P-450 Enzyme Inducers Molecular Mechanisms of Pharmacological Action Adjuvants, Anesthesia Anesthetics, Intravenous Anesthetics, General Anesthetics Central Nervous System Depressants |