Alzheimer's Disease Genetics Study (NCRAD)
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| ClinicalTrials.gov Identifier: NCT00064870 |
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Recruitment Status :
Recruiting
First Posted : July 16, 2003
Last Update Posted : March 1, 2023
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Sponsor:
Indiana University
Collaborator:
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Tatiana Foroud, Indiana University
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Brief Summary:
The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multiple members diagnosed with AD or dementia.
| Condition or disease |
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| Alzheimer Disease Late Onset Alzheimer Disease Dementia |
The purpose of the Alzheimer's Disease Genetics Study is to help identify the genes that may be responsible for causing Alzheimer's Disease (AD) by collecting genetic material from families with multiple members diagnosed with AD. Qualifying families will have two living blood-related individuals who have been diagnosed with or are showing symptoms of AD or dementia. Local study sites are located all over the United States, and arrangements may be made for eligible families who do not live near a participating site. The biological samples and data from these families will be made available to qualified researchers, who must sign a Materials Transfer Agreement (MTA) in order to protect the privacy rights of study participants before receiving samples and data.
| Study Type : | Observational |
| Estimated Enrollment : | 10000 participants |
| Observational Model: | Cohort |
| Time Perspective: | Prospective |
| Official Title: | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) |
| Study Start Date : | June 2002 |
| Estimated Primary Completion Date : | July 2026 |
| Estimated Study Completion Date : | July 2026 |
Resource links provided by the National Library of Medicine
MedlinePlus Genetics related topics:
Alzheimer disease
Primary Outcome Measures :
- Distribute biological specimens to qualified investigators for use in their research studies. [ Time Frame: Contact investigators annually for an update on progress and publication status. ]Investigators will analyze the samples and publish de-identified results. These publications will help to further the knowledge in the field of dementia and potentially lead to new therapies and targets for therapies.
Biospecimen Retention: Samples With DNA
blood samples, brain tissue, cell lines
Information from the National Library of Medicine
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| Ages Eligible for Study: | Child, Adult, Older Adult |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
Families with two or more members with Alzheimer's disease or dementia
Criteria
Inclusion Criteria:
- Two living family members diagnosed with AD or other dementia with any age of onset
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Biological samples available
- Fresh blood, or
- Immortalized lymphoblastic cell lines, or
- 3-5 grams of frozen cerebral cortex; fixed samples are not accepted
Please note: this study does not include genetic counseling; because no personal identifying information such as name or date of birth is attached to samples, results of individual tests are not available to participants or family members.
Exclusion Criteria:
- Does not meet inclusion criteria
- Member of a family that was included in the National Institute of Mental Health AD Genetics Sib Pair collection
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00064870
Contacts
| Contact: Study Coordinator | 1-800-526-2839 | alzstudy@iu.edu |
Locations
| United States, Indiana | |
| Participants are being recruited from all over the United States | Recruiting |
| Multiple Locations, Indiana, United States, 46202 | |
| Contact: NCRAD Study Coordinator 800-526-2839 alzstudy@iu.edu | |
Sponsors and Collaborators
Indiana University
National Institute on Aging (NIA)
Investigators
| Principal Investigator: | Tatiana M. Foroud, PhD | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University |
Additional Information:
| Responsible Party: | Tatiana Foroud, Department Chair, Indiana University |
| ClinicalTrials.gov Identifier: | NCT00064870 |
| Other Study ID Numbers: |
IA0042 U24AG021886 ( U.S. NIH Grant/Contract ) NIH grant U24 AG21886 |
| First Posted: | July 16, 2003 Key Record Dates |
| Last Update Posted: | March 1, 2023 |
| Last Verified: | February 2023 |
Keywords provided by Tatiana Foroud, Indiana University:
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Alzheimer disease Late Onset Alzheimer disease risk factor genes Genetics Initiative Dementia |
Additional relevant MeSH terms:
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Alzheimer Disease Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Tauopathies Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders |