Antisocial Behavior: Passing From Parent to Child to Grandchild
|ClinicalTrials.gov Identifier: NCT00060788|
Recruitment Status : Unknown
Verified March 2006 by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Recruitment status was: Recruiting
First Posted : May 14, 2003
Last Update Posted : March 7, 2006
|Condition or disease|
|Dyssocial Behavior Antisocial Personality Disorder|
While it is well-known that antisocial behavior runs in families, little is known about the specific mechanisms by which it is transmitted from one generation to the next. This prospective study will examine biological influences on transgenerational continuity and change, and how biology interacts with social factors in modulating the transmission of antisocial behavior. The study is unique in that it includes both mothers and fathers, focuses on early mechanisms, and addresses female as well as male antisocial behavior.
This study is part of the continuing Mauritius Child Health Project. The project began by testing 1,795 children age 3 years old on psychophysiological, behavioral, nutritional, and cognitive measures. Both male and female children were tested. Their parents were also assessed for psychosocial influences. One hundred children then participated in a nutritional, exercise, and educational enrichment intervention from ages 3 to 5 years old. The intervention has been shown to increase physiological arousal and attention at age 11 years and to reduce conduct disorder at age 17 years.
These 3-year-old children are now 30-year-old adults. This study will retest these adults on psychophysiological, psychosocial, cognitive, behavioral, parenting, and antisocial behavior measures. Their previously untested spouses will also be assessed. Finally, many of these adults now have 3-year-old children of their own; these children will be evaluated as well. Measures of life stress, daily hassles, family conflict, mental illness, and criminal behavior will be assessed. Data from the enrichment cohort will be evaluated to determine if the intervention disrupted the intergenerational transmission of antisocial behavior from the second to third generations.
|Study Type :||Observational|
|Estimated Enrollment :||663 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Intergenerational Transmission of Antisocial Behavior|
|Study Start Date :||September 2001|
|Estimated Study Completion Date :||December 2005|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00060788
|Joint Child Health Project||Recruiting|
|Quatre Bornes, Mauritius|
|Contact: Hughon Sophie, B.A. 230-453-9123|
|Principal Investigator:||Adrian Raine||University of Southern California|