The Psychobiology of Childhood Temperament

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2015 by National Institutes of Health Clinical Center (CC)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) ) Identifier:
First received: May 12, 2003
Last updated: October 8, 2015
Last verified: September 2015

The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's temperament.

Studies suggest that the risk for developing mood and anxiety disorders in preschool children may be linked to differences in temperament. The relationship between temperament and risk or resilience may reflect the influences of brain activity on behavior at different stages of childhood development. Behavioral inhibition and mood or anxiety disorders have been linked to disturbances in the circuitry of several areas in the brain. However, the involvement of this circuitry in temperament remains unclear. This study will use functional magnetic resonance imaging (fMRI) to examine the function of different parts of the brain in children who have previously undergone temperament studies and have had their temperaments classified.

This study will comprise three clinic visits. At Visit 1, children and their parents will meet with study staff individually and together for psychiatric interviews. Children will undergo a physical examination, medical history, a urine drug test, and practice in an fMRI simulator. Saliva samples will be collected from the children and tests will be given to assess stage of puberty, temperament, intelligence, feelings, experiences, and behavior. Other visits include fMRI scans of the brain and other tasks.

Mood Disorders
Anxiety Disorders

Study Type: Observational
Official Title: The Psychobiology of Temperament: An fMRI Study

Resource links provided by NLM:

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 980
Study Start Date: May 2003
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Ages Eligible for Study:   7 Years to 25 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Consent: Can give consent/assent.

IQ: All subjects will have IQ greater than 70.

Psychopathology: All subjects will be free of lifetime history of psychosis and pervasive developmental disorder.


Any chronic or acute medical condition severe enough to interfere with task performance or completion of questionnaires.

Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye, dental braces).

Any current axis I psychiatric disorder necessitating acute treatment.



  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00060775

Contact: Adina Heckelman (240) 723-0925
Contact: Daniel S Pine, M.D. (301) 594-1318

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010   
University of Maryland, College Park Recruiting
College Park, Maryland, United States
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
Principal Investigator: Daniel S Pine, M.D. National Institute of Mental Health (NIMH)
  More Information

Additional Information:
Responsible Party: National Institutes of Health Clinical Center (CC) ( National Institute of Mental Health (NIMH) ) Identifier: NCT00060775     History of Changes
Other Study ID Numbers: 030186, 03-M-0186
Study First Received: May 12, 2003
Last Updated: October 8, 2015
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Magnetic Resonance Imaging
Affective Neuroscience
Behavioral Inhibition
Normal Volunteers
Healthy Volunteer

Additional relevant MeSH terms:
Anxiety Disorders
Mood Disorders
Mental Disorders
Pathologic Processes processed this record on November 25, 2015