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Aortic Calcium: Epidemiology and Progression -- Ancillary to MESA

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ClinicalTrials.gov Identifier: NCT00059124
Recruitment Status : Completed
First Posted : April 18, 2003
Last Update Posted : July 12, 2013
Sponsor:
Collaborator:
Information provided by (Responsible Party):

Study Description
Brief Summary:
To study the epidemiology of aortic calcium.

Condition or disease
Cardiovascular Diseases Heart Diseases Atherosclerosis Coronary Arteriosclerosis

Detailed Description:

BACKGROUND:

Aortic calcium measured by computed tomography occurs earlier in life than other subclinical (that is, asymptomatic) markers of cardiovascular disease (CVD), shows a wide range, and is common in women. The large size of the aorta and relative lack of image artifact from motion make it ideal for radiographic quantitative imaging. This study is ancillary to and coordinated with the Multi-Ethnic Study of Atherosclerosis (MESA), a large prospective epidemiologic study investigating multiple subclinical CVD measures and CVD risk factors. Subclinical measures in MESA include coronary calcium, carotid ultrasound, cardiac magnetic resonance imaging, and the ankle/brachial blood pressure index. The extensive CVD risk factor measurements include both traditional risk factors and newer measures such as inflammatory and genetic markers.

DESIGN NARRATIVE:

This ancillary study will determine the epidemiology of aortic calcium in 2000 randomly selected (from 6500 total) MESA participants. Questions to be addressed include predictors of aortic calcium progression; associations of aortic calcium and aortic calcium progression with other subclinical CVD measures, CVD risk factors, and demographics; and the prognostic significance of aortic calcium. The project has three primary specific aims: 1) to predict the cross-sectional aortic calcium burden as a function of other subclinical CVD measures and CVD risk factors; 2) to predict aortic calcium progression as a function of other subclinical CVD measures and CVD risk factors, and 3) to predict aortic calcium progression as a function of progression of selected subclinical CVD measures and CVD risk factors. The two secondary specific aims are 1) to contrast the results of the three primary specific aims for men vs. women, and for four major ethnic groups (White, Hispanic, Black, and Asian); and 2) to provide a database for future evaluation of whether aortic calcium and/or aortic calcium progression independently predict subsequent myocardial infarction, stroke, and other CVD events.


Study Design

Study Type : Observational
Actual Enrollment : 1980 participants
Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Aortic Calcium: Epidemiology and Progression
Study Start Date : March 2003
Primary Completion Date : February 2008
Study Completion Date : February 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Calcium
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Primary Outcome Measures :
  1. Abdominal Aortic Calcium [ Time Frame: During the Exam 2 and Exam 3 MESA visits ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 84 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
A random selection of approximately 1/3 of the original MESA participants.
Criteria
Participation in the original MESA Study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00059124


Sponsors and Collaborators
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Michael H Criqui, MD, MPH University of California, San Diego
More Information

Responsible Party: Dr. Michael H. Criqui, Distinguished Professor, University of California, San Diego
ClinicalTrials.gov Identifier: NCT00059124     History of Changes
Other Study ID Numbers: 1213
R01HL072403 ( U.S. NIH Grant/Contract )
First Posted: April 18, 2003    Key Record Dates
Last Update Posted: July 12, 2013
Last Verified: July 2013

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Atherosclerosis
Arteriosclerosis
Coronary Artery Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Vascular Diseases
Coronary Disease