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Brain Use of Sensory Information to Generate Movement

This study has been completed.
Information provided by:
National Institutes of Health Clinical Center (CC) Identifier:
First received: February 22, 2003
Last updated: March 3, 2008
Last verified: January 2006

This study will use transcranial magnetic stimulation (TMS) to investigate functions of brain regions that may use information from sensory organs, such as the eyes or ears, to generate movements.

For TMS, a wire coil is held over the scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. This may cause a pulling sensation on the skin under the coil and twitching in muscles of the face, arm, or leg. During the stimulation, the participant may be asked to tense certain muscles slightly or perform other simple actions.

Healthy normal volunteers 18 years of age and older may be eligible for this study. Individuals with a history of neuropsychiatric disorders, brain lesions such as tumors, stroke, or trauma, or a history of significant medical disorders, such as cancer, may not participate. Candidates will be screened with a medical history, brief physical examination, and questionnaire.

Participants will be presented a sequence of shapes (circles, rectangles, and triangle) and will count the number of a specified shape. Each number is assigned to a corresponding response button. The subject will push the appropriate button with the corresponding finger. During these experiments, the scalp will be stimulated by TMS. Each set of TMS measurements will take up to 3-1/2 hours.


Study Type: Observational
Official Title: Role of Multimodal Areas for Sensory-To-Motor Processing

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 40
Study Start Date: February 2003
Estimated Study Completion Date: January 2006
Detailed Description:
The role of multimodal brain regions for sensory-to-motor processing is not well understood. In our recent neuroimaging study with fMRI, we found that multimodal areas such as the right superior temporal cortex and right dorsal premotor cortex were activated during sensory instructed movements. These regions might contribute to extract common features or concepts from sensory stimuli, but we do not have firm experimental evidence yet. In order to investigate the functional roles of multimodal brain regions further, we propose to apply a transcranial magnetic stimulation (TMS) technique. TMS can create transient brain lesions allowing functional mapping of cortical regions. In this protocol, by stimulating the multimodal areas using TMS, we will determine the functional role of these areas.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes


Forty normal volunteers will be included. Normal volunteers would be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in this study should have a valid Clinical Center Medical Record Number. Procedures for the experiment will follow the Standard Operating Procedures of HMCS TMS group.


Contraindications for TMS;

Magnetic stimulation will not be performed in people who have pacemakers, implanted pumps or stimulators, or have metal objects inside the eye or skull. If the participants find the procedures too uncomfortable, they may discontinue the study at any time. Brain functions at a development stage are out of scope of this particular experiment. In this study, subjects 18 years or older will be included.

Contraindications for MRI;

Pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, insulin pump, or shrapnel fragments. Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye which they may be unaware. Subjects will be screened for these contraindications prior to the study.

Subjects with previous or current neuropsychiatric disorders will be excluded. Patients with MRI findings consistent with organic brain lesions such as brain tumors, stroke, or trauma will be excluded. Subjects not capable of giving informed consent will be excluded.

We will not scan pregnant women with MRI because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subject of childbearing potential prior to MRI scan. Brain functions at a developmental stage are out of scope of this particular experiment. In this study, subjects aged 18 years or older will be included.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00055289

United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
  More Information

Publications: Identifier: NCT00055289     History of Changes
Other Study ID Numbers: 030112
Study First Received: February 22, 2003
Last Updated: March 3, 2008

Keywords provided by National Institutes of Health Clinical Center (CC):
Transcranial Magnetic Stimulation
Sensorimotor Integration
Superior Temporal Cortex
Dorsal Premotor Cortex
Healthy Volunteer
HV processed this record on August 17, 2017