Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
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|ClinicalTrials.gov Identifier: NCT00055055|
Recruitment Status : Recruiting
First Posted : February 17, 2003
Last Update Posted : April 14, 2021
This study will examine families in which one sibling of a sibling pair, or twin pair, has developed a systemic rheumatic disease and one has not, to see if and how the two differ in the following:
- Blood cell metabolism;
- Types of cells in the blood;
- Environmental exposures or genetic factors that might explain why one developed disease and the other did not.
Families in which one sibling has developed a systemic rheumatic disease, rheumatoid arthritis, systemic lupus erythematosus, scleroderma, dermatomyositis, or myositis, and the other has not, are eligible for this study. The siblings may or may not be twins, but must be of the same gender and be within a 5-year age difference. Biological parents, or, in some cases, children, will also be included in the study. Normal, healthy volunteers will serve as control subjects.
Participants will undergo some or all of the following tests and procedures:
- Medical history and physical examination. Participants will also be asked permission to obtain medical records for review.
- Questionnaires about environmental exposures at work, at home, and elsewhere. Probands (participants with rheumatic disease) and their healthy siblings will also answer questions about infections, vaccinations, medications or dietary supplements, sun exposure, and stressful events during the year before disease diagnosis in the affected sibling.
- Blood and urine collection for the following tests:
- Routine blood chemistries and other studies to rule out certain diseases or medical problems;
- Evidence of past toxic exposures and certain infections;
- Presence of cells from the mother in the child s blood and vice versa. (Recent studies suggest that during pregnancy or delivery, cells from the mother and baby may be exchanged and circulate in the body for many years, possibly causing problems);
- In twin or sibling pairs, presence of certain genes that may be more common in patients with systematic rheumatic diseases as compared with their unaffected siblings and normal volunteers;
- In identical twins, comparison of their blood cell metabolism to see if and how the metabolism differs in people with rheumatic disease.
Participants may be asked for permission to have some of their blood and urine samples stored and to obtain previously collected blood or tissue biopsy specimens that are no longer needed for clinical care, for research purposes. They may also be asked to give additional blood or urine samples.
Participants will be followed every year for 5 years (either in person or by questionnaire) to evaluate any changes in their condition. The final 5-year evaluation will repeat some of the questionnaires and procedures described above.
|Condition or disease|
|Rheumatoid Arthritis Systemic Lupus Erythematosus Idiopathic Inflammatory Myopathies|
|Study Type :||Observational|
|Estimated Enrollment :||1550 participants|
|Official Title:||Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders|
|Actual Study Start Date :||April 21, 2003|
A healthy individual who has not used any NSAIDS, with no infectious disease, or severe trauma within 8 weeks of enrollment, doesn't have a first degree relatives with RA, SLE, SSc or IIM
Parent of Proband
Biological mother or father of the proband who is willing to enroll in the study
Primary Unaffected Dizygous Twin
Dizygotic twin pair of the proband who does not meet criteria for one of the rheumatic diseases
Primary Unaffected Monozygous Twin
Monozygotic twin pair of the proband who does not meet criteria for one of the rheumatic diseases
Primary Unaffected Non-twin Sibling
Sibling of the same biological parents, same gender, within 5 years of age of the proband who does not meet criteria for one of the rheumatic diseases
Proband should have documented evidence that he/she meets criteria for adult and juvenile forms of systemic rheumatic disorders
- Physician Global Assesment Questionnaire [ Time Frame: At enrollment and each study ]Evaluate core set disease activity, damage and quality of life measures in adult and juvenile myositis patients
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00055055
|Contact: Lisa G Rider, M.D.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Lisa G Rider, M.D.||National Institute of Environmental Health Sciences (NIEHS)|