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Treatment of Post Traumatic Stress Disorder in Patients With Other Mental Illnesses

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ClinicalTrials.gov Identifier: NCT00053690
Recruitment Status : Completed
First Posted : February 5, 2003
Last Update Posted : September 10, 2013
National Institute of Mental Health (NIMH)
Information provided by:
Dartmouth-Hitchcock Medical Center

Brief Summary:
The purpose of this study is to develop an effective treatment for people with Post Traumatic Stress Disorder (PTSD) along with other mental illnesses.

Condition or disease Intervention/treatment
Stress Disorders, Post-Traumatic Behavioral: Cognitive Behavior Treatment

Detailed Description:

Despite the progress in treating PTSD in the general population and the elevated prevalence of PTSD in people with severe mental illness (SMI), there are no empirically validated treatments designed for patients with comorbid PTSD. The cognitive behavioral treatment provided in this study may improve knowledge of PTSD, decrease distorted beliefs, reduce PTSD symptoms, and improve quality of life.

Participants are randomly assigned to receive either a cognitive behavioral treatment plus standard care for SMI or standard care alone. The cognitive behavioral treatment incorporates several common features, including psychoeducation, relaxation training, and cognitive restructuring. Standard care for SMI includes medication, case management, and psychosocial treatment. PTSD, psychiatric symptoms, health, quality of life, and substance abuse outcomes are measured. Participants' knowledge of PTSD and beliefs about the world are also measured. Participants are assessed at baseline, post-treatment (16 weeks), and at 3- and 6-month follow-ups.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 88 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cognitive-Behavioral Treatment of PTSD in SMI Clients
Study Start Date : January 2002
Estimated Study Completion Date : December 2004

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U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Post Traumatic Stress Disorder
  • New Hampshire definition of SMI plus DSM-IV Axis I diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or major depression
  • Case management services and contact with a case manager at least twice a week

Exclusion Criteria:

  • Alcohol or drug dependence
  • Hospitalization or suicide attempt in the past 2 months

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00053690

United States, New Hampshire
Community Mental Health Centers in NH
Claremont, New Hampshire, United States, 03301
Sponsors and Collaborators
Dartmouth-Hitchcock Medical Center
National Institute of Mental Health (NIMH)
Principal Investigator: Kim Mueser, Ph.D. Dartmouth-Hitchcock Medical Center
Principal Investigator: Stanley Rosenberg, Ph.D. Dartmouth-Hitchcock Medical Center

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00053690     History of Changes
Other Study ID Numbers: R01MH064662-01 ( U.S. NIH Grant/Contract )
First Posted: February 5, 2003    Key Record Dates
Last Update Posted: September 10, 2013
Last Verified: February 2009

Keywords provided by Dartmouth-Hitchcock Medical Center:
Bipolar Disorder

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Trauma and Stressor Related Disorders
Mental Disorders