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Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00051207
First Posted: January 8, 2003
Last Update Posted: June 25, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Pittsburgh
  Purpose
This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.

Condition Intervention Phase
Depression Anxiety Disorders Panic Disorder Behavioral: Interpersonal Psychotherapy (IPT) Behavioral: IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS) Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Estimated Enrollment: 36
Study Start Date: November 2002
Study Completion Date: August 2005
Detailed Description:

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

  • History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.
  • History of schizophrenia or schizoaffective disorder.
  • Organic affective syndrome.
  • Unspecified functional psychosis.
  • Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.
  • Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.
  • DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.
  • Inpatient treatment due to suicide risk or psychotic symptoms.
  • Index episode secondary to the effect of medically prescribed drugs.
  • Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.
  • Medical illness that would interfere with the best treatment strategy for the potential participant.
  • Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.
  • Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00051207


Locations
United States, Pennsylvania
Western Psychiatric Institute and Clinic - Depression and Manic Depression Program
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
  More Information

ClinicalTrials.gov Identifier: NCT00051207     History of Changes
Other Study ID Numbers: R21MH061948 ( U.S. NIH Grant/Contract )
DSIR AT-AS
First Submitted: January 7, 2003
First Posted: January 8, 2003
Last Update Posted: June 25, 2013
Last Verified: December 2007

Keywords provided by University of Pittsburgh:
Mood Disorders
Psychotherapy
Comorbidity

Additional relevant MeSH terms:
Disease
Depression
Depressive Disorder
Anxiety Disorders
Panic Disorder
Pathologic Processes
Behavioral Symptoms
Mood Disorders
Mental Disorders