Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
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ClinicalTrials.gov Identifier: NCT00047996 |
Recruitment Status :
Recruiting
First Posted : October 23, 2002
Last Update Posted : February 16, 2021
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Condition or disease |
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Sickle Cell Disease |
Study Type : | Observational |
Estimated Enrollment : | 2000 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Human Specimen Collection to Support Basic and Clinical Research |
Actual Study Start Date : | November 4, 2002 |

Group/Cohort |
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Subjects ages 2 and up
Clinical Center Patients, Children at CNMC, Healthy Volunteers
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- Evaluating the role of nitric oxide, inflammatory mediators, and endothelial function in inflammatory diseases of the vasculaturesuch as sickle cell disease, coronary artery disease, pulmonary vascular or advanced lung disease, malaria, and s... [ Time Frame: Ongoing ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
- INCLUSION CRITERIA:
Males or females of age 18 years and older can be included in the study.
EXCLUSION CRITERIA:
Individuals without sickle cell disease or other chronic anemias who wish to donate blood will be excluded if the hemoglobin is less than 10 g/dL for women or less than 12g/dL for men.
Individuals with sickle cell disease or other chronic anemias will be excluded from donating blood samples if the hemoglobin is less than 6 g/dL.
A participant s most recent CBC result, obtained in the past 12 months, will be used to determine eligibility.
There are no exclusion criteria for participants donating saliva or urine.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00047996
Contact: James Nichols, R.N. | (301) 755-7432 | jnichols@mail.nih.gov | |
Contact: Arun S Shet, M.D. | (301) 827-6808 | arun.shet@nih.gov |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov |
Principal Investigator: | Arun S Shet, M.D. | National Heart, Lung, and Blood Institute (NHLBI) |
Responsible Party: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00047996 |
Other Study ID Numbers: |
030015 03-H-0015 |
First Posted: | October 23, 2002 Key Record Dates |
Last Update Posted: | February 16, 2021 |
Last Verified: | February 4, 2021 |
DNA Endothelial Function Leukocyte Gene Expression RNA Sickle Cell |
Coronary Artery Disease CAD Healthy Volunteer HV |
Anemia, Sickle Cell Anemia, Hemolytic, Congenital Anemia, Hemolytic Anemia |
Hematologic Diseases Hemoglobinopathies Genetic Diseases, Inborn |