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Nevada Environmental Tobacco Smoke and Health Study

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ClinicalTrials.gov Identifier: NCT00046306
Recruitment Status : Completed
First Posted : September 30, 2002
Last Update Posted : January 14, 2013
Information provided by:

Study Description
Brief Summary:

Workplace exposure to secondhand cigarette smoke or environmental tobacco smoke (ETS)is widespread, effecting between 19 and 49% of the U.S. workforce. The first part of this study is designed to test whether exposure to ETS in the workplace effects a person's risk of developing chronic diseases such as cardiovascular disease and cancer. The second part of this study is designed to test whether antioxidant supplementation in this group of ETS exposed individuals can reduce their risk of developing chronic disease.

The study will look at 375 non-smokers who either work on a casino floor or as bartenders or cocktail servers. Initial baseline data will be collected (questionnaires and blood samples taken) and the subjects will be randomized into one of three groups, placebo, low antioxidant supplementation and high antioxidant supplementation. They will be followed over a two-year period, coming in for follow-up testing every six months. Statistical analysis will be conducted to see whether this group of ETS exposed individuals has a greater risk of developing chronic disease and whether the use of antioxidant supplements can moderate any risks.

Condition or disease Intervention/treatment Phase
Cardiovascular Disease Cancer Drug: Antioxidants Phase 3

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 375 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double
Primary Purpose: Prevention
Study Completion Date : August 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antioxidants
U.S. FDA Resources

Arms and Interventions

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   22 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

Non-smoker Work in a casino - on the casino floor or work as a bartender or cocktail server for at least 1 year Do not take antioxidant supplements Healthy - not diagnosed with any major chronic diseases.

Exclusion Criteria:

Blood pressure SBP>200,<85 DBP>100, <40 Pulse >120, <45 Cholesterol >400 Triglycerides >700 Blood Cotinine >10 ng/ml BMI >35

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00046306

United States, Nevada
ETS Clinic, University of Nevada, School of Medicine, 1707 W. Charleston Blvd Suite 100
Las Vegas, Nevada, United States, 89102
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: Chris A Pritsos, Ph.D. University of Nevada, Reno
More Information

ClinicalTrials.gov Identifier: NCT00046306     History of Changes
Other Study ID Numbers: 9520-CP-001
First Posted: September 30, 2002    Key Record Dates
Last Update Posted: January 14, 2013
Last Verified: January 2013

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Oxidative Stress
Cardiovascular Disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs