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Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill

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ClinicalTrials.gov Identifier: NCT00045799
Recruitment Status : Completed
First Posted : September 11, 2002
Last Update Posted : November 25, 2019
Sponsor:
Information provided by (Responsible Party):
Bausch Health Americas, Inc.

Study Description
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Brief Summary:
Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage. Cimetidine, delivered continuously through intravenous infusion, is the only drug that the FDA has approved for the prevention of upper GI bleeding in critically ill patients. The present trial is intended to assess the safety and efficacy of an omeprazole sodium bicarbonate immediate-release suspension in this indication.

Condition or disease Intervention/treatment Phase
Upper Gastrointestinal Bleeding Drug: Omeprazole sodium bicarbonate immediate release PWD/FS Drug: Cimetidine IV Phase 3

Detailed Description:
This trial will be a triple-blind, double-dummy, prospective, multicenter, randomized clinical trial comparing the effectiveness of OSB-IR to the effectiveness of intravenous cimetidine in preventing upper GI bleeding at risk for SRMD.
Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 354 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
Official Title: Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill
Study Start Date : May 2002
Actual Study Completion Date : May 2003

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Arms and Interventions
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Arm Intervention/treatment
Experimental: Omeprazole sodium bicarbonate immediate release PWD/FS Drug: Omeprazole sodium bicarbonate immediate release PWD/FS
Active Comparator: Cimetidine IV Drug: Cimetidine IV


Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Patients will be included in the trial if they meet all of the following criteria:

  1. An adult or adolescent (greater than or equal to 16 years of age) male or non-pregnant female requiring mechanical ventilation for greater than or equal to 48 hours.
  2. An anticipated ICU stay of greater than or equal to 72 hours.
  3. An Acute Physiology and Chronic Health Evaluation (APACHE II) score of >11 immediately before randomization.

  4. At least one other risk factor for upper GI bleeding due to stress-related mucosal damage in addition to mechanical ventilation. Acceptable "other" risk factors include:

    • closed-head injury
    • multiple trauma to head, chest, abdomen, solid organs, or limbs
    • major surgical procedures (eg, mastectomy, pancreatectomy, cardiovascular surgery) 24 hours previous to screening
    • extensive burns (greater than or equal to 30% of the body surface area)
    • acute renal failure (urine output <0.5 mL/kg of body weight/hr for one hour, despite adequate fluid resuscitation)
    • acid-base disorder (pH less than or equal to 7.3 or base deficit greater than or equal to 5.0 mMol/L with a plasma lactate level >1.5 times the upper limit of normal for the reporting laboratory)
    • coagulopathy (a platelet count <50,000/mm3, an INR of >1.5 [i.e., prothrombin time >1.5 times the control value], or a partial-thromboplastin time >2.0 times the control value)
    • marked jaundice (defined as plasma total bilirubin concentration of >51.3 micromol/L or >3 mg/dL)
    • coma
    • hypotension (either a systolic blood pressure <80 mm Hg for 2 hours or more or a decrease of greater than or equal to 30 mm Hg in the systolic blood pressure)
    • shock (arterial blood pressure less than or equal to 90 mm Hg or mean arterial pressure less than or equal to 70 mm Hg for at least one hour despite adequate fluid resuscitation, adequate intravascular volume status or the use of vasopressors in an attempt to maintain a systolic blood pressure of greater than or equal to 90 mm Hg or a mean arterial pressure of greater than or equal to 70 mm Hg)
    • sepsis (defined as a positively cultured or clinically diagnosed infection with at least three of the following: a body temperature of greater than or equal to 38 degrees C [greater than or equal to 100.4 degrees F] or less than or equal to 36 degrees C [less than or equal to 96.8 degrees F], a heart rate of greater than or equal to 90 beats/min, tachypnea manifested by a respiratory rate of greater than or equal to 20 breaths/min, or hyperventilation as indicated by a PaCO2 of less than or equal to 32 mm Hg, and a white blood cell count of greater than or equal to 12,000 cells/mm3 or less than or equal to 4,000 cells/mm3, or the presence of >10% bands)
  5. An intact stomach and a nasogastric or an orogastric tube in place.
  6. An anticipation of no enteral feedings for the first two days of trial drug treatment.

Exclusion Criteria

Patients will be excluded from trial participation if they meet any of the following criteria:

  1. A status of "No Cardiopulmonary Resuscitation (CPR)".
  2. If >48 hours has elapsed since the patient became eligible for the trial.
  3. Known history of vagotomy, pyloroplasty, gastroplasty, or any other gastric surgery.
  4. Known allergy to cimetidine or omeprazole.
  5. Active GI bleeding (including esophageal and gastric variceal bleeding, duodenal and gastric ulcers).
  6. Significant risk of swallowing blood (i.e., severe facial trauma, oral lacerations, hemoptysis).
  7. Enteral feedings for the first two days of trial drug treatment.
  8. Use of an investigational drug within 30 days prior to randomization.
  9. Critical/intensive care unit admission following esophageal, gastric, or duodenal surgery or trauma.
  10. Known history of upper gastrointestinal lesions that are likely to bleed (e.g., esophageal or gastric varices, gastric polyps, tumors, etc. but excluding patients with gastric or duodenal ulcer disease).
  11. Any medical or surgical condition that precludes administration of an oral medication (i.e., OSB-IR).
  12. End stage liver disease.
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00045799


Locations
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Sponsors and Collaborators
Bausch Health Americas, Inc.
More Information
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Responsible Party: Bausch Health Americas, Inc.
ClinicalTrials.gov Identifier: NCT00045799    
Other Study ID Numbers: OSB-IR C03
First Posted: September 11, 2002    Key Record Dates
Last Update Posted: November 25, 2019
Last Verified: November 2019
Additional relevant MeSH terms:
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Gastrointestinal Hemorrhage
Hemorrhage
Pathologic Processes
Gastrointestinal Diseases
Digestive System Diseases
Omeprazole
Cimetidine
Anti-Ulcer Agents
Gastrointestinal Agents
Proton Pump Inhibitors
 Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Histamine H2 Antagonists
Histamine Antagonists
Histamine Agents
Neurotransmitter Agents
Physiological Effects of Drugs
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors