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Outdoor Allergen Exposure, Sensitivity, and Acute Asthma

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ClinicalTrials.gov Identifier: NCT00043992
Recruitment Status : Completed
First Posted : August 19, 2002
Last Update Posted : September 4, 2006
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
To examine the role of outdoor pollen grains and fungal spores in the exacerbation of asthma and to produce forecasting models to predict days of high concentration.

Condition or disease
Asthma

Detailed Description:
Asthma is a growing problem, and outdoor allergens play a role in exacerbation of many cases. A clearer understanding of this role and its magnitude, and a means of controlling the effects of outdoor allergen exposures is needed. We propose Poisson time-series and conditional panel studies to test these hypotheses: 1) The incidence of acute asthma attacks, as measured by urgent care inhalation treatments and hospitalizations for asthma, has a dose-dependent relationship with exposure to specific outdoor allergens; 2) Specific sensitization to outdoor allergens is a risk factor for having an acute attack; and 3) Exposure conditions that lead to acute asthma attacks can be forecast, creating an opportunity to reduce asthma morbidity and mortality ny targeting pretreatment and/or exposure controls.

Study Type : Observational
Enrollment : 1000 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Study Start Date : July 2001

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
U.S. FDA Resources





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Ages Eligible for Study:   15 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Must be a member of the Fallon HMO and be treated for acute asthma exacerbation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00043992


Locations
United States, Massachusetts
Fallon Clinic and Fallon Community Health Plan
Worcester, Massachusetts, United States, 01605
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)

ClinicalTrials.gov Identifier: NCT00043992     History of Changes
Other Study ID Numbers: 9744-CP-001
First Posted: August 19, 2002    Key Record Dates
Last Update Posted: September 4, 2006
Last Verified: September 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Asthma
Allergens

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases