Socio-economic Status and Age-related Disability in a Biracial Community

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00042133
Recruitment Status : Completed
First Posted : July 26, 2002
Last Update Posted : April 14, 2015
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
The overall goal of the proposed project is to examine the reasons for the higher levels of disability in older people of lower socio-economic status.

Condition or disease

Detailed Description:

This application is a continuation of an epidemiologic study that investigates the effect of socio-economic disadvantage and neighborhood conditions on disability in older blacks and whites. The proposed project takes place in the context of a population-based, longitudinal study of persons aged 65 years and over who live in a geographically defined, urban, biracial community area in Chicago. During the initial funding period, we have successfully collected yearly disability outcome data, and detailed information on neighborhood conditions using self-report instruments and a systematic neighborhood survey of study area.

The first overall goal of this continuation is to determine the relative contribution and specific nature of the neighborhood conditions that are associated with disability in older adults. The second overall goal is to determine the biological mechanisms through which neighborhood conditions lead to increased disability, focusing specifically on hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, via salivary cortisol, and inflammatory processes, via interleukin-6 (IL-6) and C-reactive protein (CRP), obtained from blood samples. To accomplish these goals, we propose to continue yearly collection of disability outcome data and obtain blood samples and salivary cortisol from over 7,000 participants. These data will be integrated with a rich set of existing data on personal characteristics, health conditions, and neighborhood factors to test of series of specific hypotheses related to the overall goals.

Disability is a common and highly prevalent consequence of age-related chronic diseases, and a critical indicator of overall health among older people. Prevention of disability is essential to improve the lives of older people and reduce health care costs. The proposed work will contribute to a better understanding of the specific neighborhood conditions that are associated with increased disability, laying the foundation for more effective policies to prevent disability in future generations of older adults.

Study Type : Observational
Estimated Enrollment : 6000 participants
Time Perspective: Prospective
Study Start Date : April 2001
Actual Primary Completion Date : July 2010
Actual Study Completion Date : July 2010

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
inclusion criteria: adults aged 65 years and over exclusion criteria: none

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00042133

United States, Illinois
Rush University Medical Center
Chicago, Illinois, United States, 60612
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: Carlos F. Mendes de Leon, Ph.D. Rush University Medical Center Identifier: NCT00042133     History of Changes
Other Study ID Numbers: 10902-CP-001
First Posted: July 26, 2002    Key Record Dates
Last Update Posted: April 14, 2015
Last Verified: April 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
longitudinal studies
neighborhood factors
socio-economic status