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Socio-economic Status and Age-related Disability in a Biracial Community

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: July 24, 2002
Last updated: April 13, 2015
Last verified: April 2015
The overall goal of the proposed project is to examine the reasons for the higher levels of disability in older people of lower socio-economic status.


Study Type: Observational
Study Design: Time Perspective: Prospective

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 6000
Study Start Date: April 2001
Study Completion Date: July 2010
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Detailed Description:

This application is a continuation of an epidemiologic study that investigates the effect of socio-economic disadvantage and neighborhood conditions on disability in older blacks and whites. The proposed project takes place in the context of a population-based, longitudinal study of persons aged 65 years and over who live in a geographically defined, urban, biracial community area in Chicago. During the initial funding period, we have successfully collected yearly disability outcome data, and detailed information on neighborhood conditions using self-report instruments and a systematic neighborhood survey of study area.

The first overall goal of this continuation is to determine the relative contribution and specific nature of the neighborhood conditions that are associated with disability in older adults. The second overall goal is to determine the biological mechanisms through which neighborhood conditions lead to increased disability, focusing specifically on hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, via salivary cortisol, and inflammatory processes, via interleukin-6 (IL-6) and C-reactive protein (CRP), obtained from blood samples. To accomplish these goals, we propose to continue yearly collection of disability outcome data and obtain blood samples and salivary cortisol from over 7,000 participants. These data will be integrated with a rich set of existing data on personal characteristics, health conditions, and neighborhood factors to test of series of specific hypotheses related to the overall goals.

Disability is a common and highly prevalent consequence of age-related chronic diseases, and a critical indicator of overall health among older people. Prevention of disability is essential to improve the lives of older people and reduce health care costs. The proposed work will contribute to a better understanding of the specific neighborhood conditions that are associated with increased disability, laying the foundation for more effective policies to prevent disability in future generations of older adults.


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
inclusion criteria: adults aged 65 years and over exclusion criteria: none
  Contacts and Locations
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Please refer to this study by its identifier: NCT00042133

United States, Illinois
Rush University Medical Center
Chicago, Illinois, United States, 60612
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: Carlos F. Mendes de Leon, Ph.D. Rush University Medical Center
  More Information Identifier: NCT00042133     History of Changes
Other Study ID Numbers: 10902-CP-001
Study First Received: July 24, 2002
Last Updated: April 13, 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
longitudinal studies
neighborhood factors
socio-economic status
race processed this record on June 22, 2017