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Treatment of Patients With Major Depressive Disorder With MK0869 (0869-073)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00042029
First Posted: July 23, 2002
Last Update Posted: May 5, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Merck Sharp & Dohme Corp.
  Purpose
A clinical study to determine the efficacy and safety of MK0869 in the treatment of depression.

Condition Intervention Phase
Major Depressive Disorder Drug: MK0869, aprepitant Drug: Comparator: placebo Phase 3

Study Type: Interventional
Study Design: Primary Purpose: Treatment
Official Title: A Double-Blind, Multicenter, Placebo-Controlled Study of MK0869 in the Treatment of Patients With Major Depressive Disorder

Resource links provided by NLM:


Further study details as provided by Merck Sharp & Dohme Corp.:

Primary Outcome Measures:
  • HAMD-17 total score; Tolerability

Secondary Outcome Measures:
  • CGI-I Scale score; Sheehan Disability Scale

Enrollment: 324
Actual Study Start Date: June 18, 2002
Study Completion Date: October 3, 2003
Primary Completion Date: October 3, 2003 (Final data collection date for primary outcome measure)
Detailed Description:
The duration of treatment is 8 weeks.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
Patients with Major Depressive Disorder
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications:
Study Data/Documents: CSR Synopsis  This link exits the ClinicalTrials.gov site

Responsible Party: Merck Sharp & Dohme Corp.
ClinicalTrials.gov Identifier: NCT00042029     History of Changes
Other Study ID Numbers: 0869-073
Formally-8DL718
MK0869-073
2006_409
First Submitted: July 22, 2002
First Posted: July 23, 2002
Last Update Posted: May 5, 2017
Last Verified: May 2017

Additional relevant MeSH terms:
Disease
Depressive Disorder
Depression
Depressive Disorder, Major
Pathologic Processes
Mood Disorders
Mental Disorders
Behavioral Symptoms
Aprepitant
Fosaprepitant
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Neurokinin-1 Receptor Antagonists
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action