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Trial record 4 of 12 for:    benzene

Modulation of Benzene Metabolism by Exposure to Environment

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00041860
First Posted: July 22, 2002
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured.

Condition Intervention
Lung Diseases Cancer Procedure: Controlled Exposure to Environmental Contaminant

Study Type: Interventional

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Detailed Description:
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured. The exposures take place in the Controlled Environmental Facility operated by the Environmental and Occupational Health Sciences Institute (EOHSI). This allows us to control the exact benzene air level and to use benzene containing 13C, a stable (non-radioactive) form of carbon, one of the atoms that make up benzene. Isotopes are different forms of the same atom. Using 13C will allow us to tell the difference between the benzene and the compounds it changes to in the body that come from our experiment compared to what is present in your body from other sources. In addition to just benzene exposure on some days the subject is also be exposed to methyl tertiary butyl ether (MTBE), another component of gasoline, to take an iron supplement pill and/or to take vitamins C and E pills. How benzene is metabolized or changed in the body will be compared for these differences to better understand how the body deals with benzene.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
  Contacts and Locations
No Contacts or Locations Provided
  More Information

ClinicalTrials.gov Identifier: NCT00041860     History of Changes
Other Study ID Numbers: 9676-CP-001
First Submitted: July 18, 2002
First Posted: July 22, 2002
Last Update Posted: December 9, 2005
Last Verified: July 2002

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Benzene
Air pollution

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases