Trial record 4 of 12 for:
benzene
Modulation of Benzene Metabolism by Exposure to Environment
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ClinicalTrials.gov Identifier: NCT00041860 |
Recruitment Status
:
Completed
First Posted
: July 22, 2002
Last Update Posted
: June 24, 2005
|
Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
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Brief Summary:
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Lung Diseases Cancer | Procedure: Controlled Exposure to Environmental Contaminant | Not Applicable |
The research is to evaluate benzene metabolism after exposure at levels that can be found in the environment, such as the higher end concentrations in the air inside cars and buses while being driven in heavy traffic and inside private and public parking garages. To do so breath, urine, and blood samples prior to, during and after being exposed to benzene as well as benzene levels and benzene metabolites present are measured. The exposures take place in the Controlled Environmental Facility operated by the Environmental and Occupational Health Sciences Institute (EOHSI). This allows us to control the exact benzene air level and to use benzene containing 13C, a stable (non-radioactive) form of carbon, one of the atoms that make up benzene. Isotopes are different forms of the same atom. Using 13C will allow us to tell the difference between the benzene and the compounds it changes to in the body that come from our experiment compared to what is present in your body from other sources. In addition to just benzene exposure on some days the subject is also be exposed to methyl tertiary butyl ether (MTBE), another component of gasoline, to take an iron supplement pill and/or to take vitamins C and E pills. How benzene is metabolized or changed in the body will be compared for these differences to better understand how the body deals with benzene.
Study Type : | Interventional (Clinical Trial) |
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Ages Eligible for Study: | Child, Adult, Senior |
No Contacts or Locations Provided
ClinicalTrials.gov Identifier: | NCT00041860 History of Changes |
Other Study ID Numbers: |
9676-CP-001 |
First Posted: | July 22, 2002 Key Record Dates |
Last Update Posted: | June 24, 2005 |
Last Verified: | July 2002 |
Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Benzene Air pollution |
Additional relevant MeSH terms:
Lung Diseases Respiratory Tract Diseases |