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Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: July 18, 2002
Last updated: March 22, 2006
Last verified: March 2006
This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Condition Intervention
Rhinitis, Allergic, Nonseasonal
Procedure: Nasal irritation thresholds and irritant provocation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind
Official Title: Individual Factors in Nasal Irritant Sensitivity

Resource links provided by NLM:

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 64
Study Start Date: September 2000

Ages Eligible for Study:   18 Years to 69 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Non-smokers
  • 18-69 years of age
  • With or without allergic rhinitis (hay fever)
  • In good general health and with no prior history of asthma
  Contacts and Locations
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Please refer to this study by its identifier: NCT00041821

United States, California
Upper Airway Biology Laboratory
Richmond, California, United States, 94804
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

Additional Information:
Publications: Identifier: NCT00041821     History of Changes
Other Study ID Numbers: 10424-CP-001
Study First Received: July 18, 2002
Last Updated: March 22, 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

Additional relevant MeSH terms:
Rhinitis, Allergic
Rhinitis, Allergic, Perennial
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on May 25, 2017