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Major Depression and Inflammatory Risk Markers for Coronary Heart Disease

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ClinicalTrials.gov Identifier: NCT00037505
Recruitment Status : Completed
First Posted : May 20, 2002
Last Update Posted : June 24, 2005
Information provided by:

Study Description
Brief Summary:
The overall purpose of this research is to examine whether depression influences immune system function. Studies indicate that individuals who are depressed experience coronary heart disease at a higher rate than expected. This study's goal is to begin identifying mechanisms that might be responsible for this process. This research also examines whether behavioral processes (e.g. smoking) or hormonal processes (e.g. adrenaline release) are responsible for immune system differences between depressed and nondepressed people

Condition or disease

Detailed Description:
To qualify for participation, subjects are to be between the ages of 18-55, medically healthy and free of all medication three months prior to enrollment. Half of them will be clinically depressed; the remaining one half will be healthy controls without a history of psychiatric illness. All subjects who qualify for the study will attend two laboratory sessions. During the first visit, participants will undergo a structured psychological interview, complete questionnaires about their mood, personality, and behavior, and have blood drawn to assess their immune system function. During the second visit, participants will complete additional questionnaires about their mood, personality, and behavior. The subjects will also participate in a mock job interview to look at their body's response to stress. Before and after the interview, the subjects will have blood drawn and be asked to collect saliva samples to assess their immune system function. In addition to the two laboratory visits, participants will be asked to collect additional information while going about their normal activities. In order to accomplish this, they will be given a small hand held portable computer. Four times each day for four days, the computer will signal them to collect a saliva sample. This will be used later to measure hormone levels. This study will explore changes in the immune system and metabolic system that might predispose depressed individuals to develop heart disease

Study Design

Study Type : Observational
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Major Depression and Inflammatory Risk Markers for Coronary Heart Disease

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   15 Years to 55 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
For eligibility, potential subjects will be 18-55 years of age, free of all medication during the past three months, and have no history of chronic illness involving the cardiovascular, endocrine, immune systems
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00037505

United States, Missouri
Washington University
St. Louis, Missouri, United States, 63130
Sponsors and Collaborators
National Center for Research Resources (NCRR)
American Heart Association
More Information

ClinicalTrials.gov Identifier: NCT00037505     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0849
First Posted: May 20, 2002    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003

Additional relevant MeSH terms:
Depressive Disorder
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases