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Genome Scan for Obesity in a Multi-Ethnic Sample

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00037271
First Posted: May 17, 2002
Last Update Posted: February 18, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
  Purpose
To scan the genome for obesity in a multi-ethnic sample.

Condition
Cardiovascular Diseases Heart Diseases Obesity

Study Type: Observational

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: April 2001
Study Completion Date: March 2003
Detailed Description:

BACKGROUND:

Despite intensive efforts the genetic basis of obesity has been difficult to establish. Linkage analysis using a genome-wide scan can potentially identify genomic regions not previously thought to be associated with susceptibility to obesity and provides a comprehensive test of the consistency of previous studies. The study used the considerable resources generated by the four cooperating networks in the NHLBI-supported "Family Blood Pressure Program" (FBPP) to conduct a genome-wide scan data for obesity.

DESIGN NARRATIVE:

In the Family Blood Pressure Program, microsatellite markers were typed at a density of -10cM by the Mammalian Genotyping Service (MGS) in Marshfield, WI. The complete data set was to include 9,940 individuals representing 4 ethnic groups (white, black, Hispanic and Asian). Obesity was characterized as a weight/height ratio (body mass index) and waist/hip ratio. This data set was larger than any prior genome scan for obesity, and the inclusion of multiple ethnic groups made it possible to examine genetic heterogeneity. The specific aims of the study were to conduct linkage and association analyses to localize regions influencing obesity. Investigators worked closely with the FBPP Coordinating Center (Washington University, St. Louis) and investigators from each of the four FBPP networks. Evidence was sought for consistency between results obtained from analyses of the genome scan performed by each of the individuals, and results summarized from the literature, with those found in meta-analysis.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria
No eligibility criteria
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00037271     History of Changes
Other Study ID Numbers: 1158
R03HL065702 ( U.S. NIH Grant/Contract )
First Submitted: May 16, 2002
First Posted: May 17, 2002
Last Update Posted: February 18, 2016
Last Verified: August 2004

Additional relevant MeSH terms:
Obesity
Cardiovascular Diseases
Heart Diseases
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms