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St. John’s Wort Vs. Placebo in Obsessive-Compulsive Disorder.

This study has been completed.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH) Identifier:
First received: May 3, 2002
Last updated: August 3, 2006
Last verified: August 2006
The purpose of this study is to determine the effectiveness of St. John’s Wort as compared to placebo (an inactive substance) in the treatment of outpatients with obsessive compulsive disorder.

Condition Intervention Phase
Obsessive Compulsive Disorder
Drug: St. John’s Wort
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: St. John’s Wort Vs. Placebo in Obsessive-Compulsive Disorder.

Resource links provided by NLM:

Further study details as provided by National Center for Complementary and Integrative Health (NCCIH):

Estimated Enrollment: 60
Study Start Date: May 2002
Estimated Study Completion Date: September 2003
Detailed Description:
The objective of the proposed study is to assess the efficacy of the herbal St. John’s Wort (SJW) in the treatment of symptoms of obsessive-compulsive disorder (OCD). The approach is to conduct a 12-week, randomized, double blind, placebo controlled, parallel group pilot trial with 30 subjects in each of two arms. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) will be the primary measure for evaluating OCD. An intention-to-treat analysis will be done to compare the two arms.

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria

  • Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception.
  • Meets DSM-IV criteria for obsessive compulsive disorder

Exclusion criteria

  • Primary diagnosis of major depression, dysthymia, panic disorder, social phobia, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD
  • Substance abuse or dependence in the past 6 months
  • Vascular dementia or primary degenerative dementia of the Alzheimer’s type
  • Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit.
  • Fluoxetine within 5 weeks of first visit.
  • Failure to respond to at least two adequate antidepressant trials for obsessive compulsive disorder
  • Investigational drugs within 30 days of baseline
  • Known allergy or hypersensitivity to St. John’s Wort
  • Currently in behavior therapy for obsessive compulsive disorder


  Contacts and Locations
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Please refer to this study by its identifier: NCT00035438

United States, Oklahoma
University of Oklahoma Health Science Center
Oklahoma City, Oklahoma, United States, 73190
United States, Wisconsin
Dean Foundation
Madison, Wisconsin, United States, 53562
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Principal Investigator: Kenneth Kobak, PhD Dean Foundation for Health, Research and Analysis
Principal Investigator: Leslie Taylo, MD Dean Foundation for Health, Research and Analysis
  More Information

Additional Information: Identifier: NCT00035438     History of Changes
Other Study ID Numbers: R21AT000391-01 ( US NIH Grant/Contract Award Number )
Study First Received: May 3, 2002
Last Updated: August 3, 2006

Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
obsessive compulsive disorder
St. John’s Wort
Mental health

Additional relevant MeSH terms:
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Compulsive Behavior
Pathologic Processes
Personality Disorders
Mental Disorders
Anxiety Disorders
Impulsive Behavior processed this record on May 25, 2017