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This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in Alzheimer's Disease (AD) primary prevention trials.
Condition or disease
This project will focus on the development and testing of efficient, cost effective measures that are specifically designed for use in AD primary prevention trials. The new or improved measures that have been developed will then be evaluated in 650 nondemented subjects enrolled in a simulated Alzheimer's disease prevention trial. Once enrolled, subjects will be followed for four years with annual clinical evaluations and interim six-month phone calls.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
75 Years and older (Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
75 years or older.
Fluent in English or Spanish.
Stable medical condition for four weeks prior to screening visit.
Stable medications for four weeks prior to screening visit.
Either cognitively normal, or mild cognitive impairment. If MCI, the subject's CDR at screening have a global score of 0.5.
mMMSE score greater than 88 for subjects with at least 8 years education, or greater than 80 for subjects with less than 8 years education, and FCSRT total free plus cued recall score greater than 44 with 3 learning trials.
Willing to participate in four to five year follow-up study.
Willing to identify person who can serve as informant.
At least six years education or work history sufficient to exclude mental retardation
Meets DSM IV criteria for dementia
History of clinically significant medical illness that would interfere with participation in trial, including active malignancy, myocardial infarction, or cerebrovascular accident within the past year
Alcohol or substance abuse and/or active major psychiatric disorders