ClinicalTrials.gov
ClinicalTrials.gov Menu

Role of Fat Tissue in Vitamin D Metabolism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00033826
Recruitment Status : Completed
First Posted : April 11, 2002
Last Update Posted : May 24, 2013
Sponsor:
Collaborator:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:
Tufts University

Brief Summary:
Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.

Condition or disease
Vitamin D Adipose Tissue

Detailed Description:
Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.

Study Type : Observational
Actual Enrollment : 41 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: The Role of Adipose Tissue in Vitamin D Metabolism
Study Start Date : April 2002
Actual Primary Completion Date : September 2007
Actual Study Completion Date : September 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Vitamin D
Drug Information available for: Vitamin D
U.S. FDA Resources





Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients from Obesity Clinic
Criteria

Inclusion Criteria:

  • Obese patients referred for gastric bypass surgery

Exclusion Criteria:

  • Patients must not be taking bile acid-sequestering medications or anti-seizure medications

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00033826


Locations
United States, Massachusetts
Tufts-New England Medical Center
Boston, Massachusetts, United States, 02111
Sponsors and Collaborators
Tufts University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Investigators
Principal Investigator: Miriam Blum, MD Jean Mayer USDA Human Nutrition Center on Aging at Tufts University

Responsible Party: Miriam Blum, MD, HNRC at Tufts
ClinicalTrials.gov Identifier: NCT00033826     History of Changes
Other Study ID Numbers: K23AR047869 ( U.S. NIH Grant/Contract )
K23AR047869 ( U.S. NIH Grant/Contract )
NIAMS-070
First Posted: April 11, 2002    Key Record Dates
Last Update Posted: May 24, 2013
Last Verified: May 2013

Keywords provided by Tufts University:
Vitamin D
Adipose tissue
Metabolism

Additional relevant MeSH terms:
Vitamins
Vitamin D
Ergocalciferols
Micronutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents