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Evaluation of Echinacea for the Common Cold
This study has been completed.
Sponsor:
National Center for Complementary and Integrative Health (NCCIH)
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)
ClinicalTrials.gov Identifier:
NCT00032500
First received: March 22, 2002
Last updated: August 17, 2006
Last verified: July 2006
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Purpose
The purpose of this study is to determine whether three Echinacea preparations with different chemical compositions are effective for prevention or treatment of the common cold.
| Condition | Intervention | Phase |
|---|---|---|
| Common Cold | Drug: Echinacea | Phase 2 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Prevention |
| Official Title: | Evaluation of Echinacea in a Human Rhinovirus Challenge |
Resource links provided by NLM:
MedlinePlus related topics:
Common Cold
Drug Information available for:
Echinacea
U.S. FDA Resources
Further study details as provided by National Center for Complementary and Integrative Health (NCCIH):
| Study Start Date: | September 2001 |
| Estimated Study Completion Date: | May 2004 |
Echinacea is a widely used herbal remedy for the common cold. Previous clinical trials designed to assess the efficacy of Echinacea for prevention or treatment of the common cold have produced inconsistent results. A variety of different Echinacea products have been used in these clinical trials. Recent studies indicate that different Echinacea preparations have dramatically different phytochemical profiles. The available clinical trial data provide no information about the potential role of the different constituents of Echinacea in common cold prevention or treatment. Our hypothesis is that the variation in reported clinical effectiveness may be due to differences in the phytochemical profile of the Echinacea preparations used. This study will address the following specific aims: 1) Evaluate the effectiveness of chemically defined extracts of E. angustifolia root which contain alkamides, echinacoside or polysaccharidelglycoprotein for common cold prevention or treatment; 2) Assess the correlation between specific Echinacea metabolites in serum and nasal secretions and efficacy for prevention and treatment of colds; and 3) Determine the effect of different Echinacea preparations on the host response to rhinovirus infection.
Eligibility| Ages Eligible for Study: | Child, Adult, Senior |
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00032500
Please refer to this study by its ClinicalTrials.gov identifier: NCT00032500
Locations
| United States, Virginia | |
| University of Virginia, Charlottesville | |
| Charlottesville, Virginia, United States, 22904 | |
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Investigators
| Principal Investigator: | Ronald B. Turner, MD | University of Virginia School of Medicine |
| OverallOfficial: | J. David Gangemi, PhD | Clemson University |
| OverallOfficial: | Rudolf Bauer, PhD | Karl-Franzens-Universitaet Graz |
More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00032500 History of Changes |
| Other Study ID Numbers: |
R01AT001146-01 ( US NIH Grant/Contract Award Number ) |
| Study First Received: | March 22, 2002 |
| Last Updated: | August 17, 2006 |
Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
|
common cold Echinacea |
Additional relevant MeSH terms:
|
Common Cold Picornaviridae Infections RNA Virus Infections |
Virus Diseases Respiratory Tract Infections Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on June 26, 2017