Celecoxib in Preventing Skin Cancer

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00025051
Recruitment Status : Withdrawn
First Posted : January 27, 2003
Last Update Posted : March 22, 2013
Information provided by:
National Cancer Institute (NCI)

Brief Summary:

RATIONALE: Celecoxib may be effective in preventing skin cancer by decreasing redness caused by exposure to ultraviolet light and changing potential skin cancer biomarkers. It is not yet known whether celecoxib is more effective than a placebo in preventing skin cancer.

PURPOSE: Randomized phase II trial to study the effectiveness of celecoxib in preventing skin cancer in participants exposed to ultraviolet light.

Condition or disease Intervention/treatment Phase
Non-melanomatous Skin Cancer Drug: celecoxib Procedure: anti-cytokine therapy Procedure: antiangiogenesis therapy Procedure: biological therapy Procedure: cancer prevention intervention Procedure: chemoprevention of cancer Procedure: growth factor antagonist therapy Phase 2

Detailed Description:


  • Determine whether celecoxib decreases ultraviolet(UV)-induced erythema and affects surrogate biomarkers of potential neoplastic change in participants with Fitzpatrick type I-IV skin exposed to UV light.

OUTLINE: This is a randomized, double-blind, placebo-controlled study. Participants are randomized to one of two treatment arms.

  • Arm I: Participants receive oral celecoxib twice daily for approximately 120 days.
  • Arm II: Participants receive oral placebo twice daily for approximately 120 days.

Skin biopsies of UV-exposed sites are evaluated.

Participants are followed for up to 5 weeks post-treatment.

PROJECTED ACCRUAL: A total of 36 participants (18 per arm) will be accrued for this study within 8 months.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Prevention
Official Title: A Phase II, Double-Blind, Placebo-Controlled Clinical Trial To Assess Celecoxib As A Chemopreventive Agent Inhibiting UV-Induced Erythema And Cutaneous Carcinogenesis As Assessed Through Surrogate Biological Markers In Biopsied Skin After Exposure Of Skin In Normal Volunteers Ages 20-60 Years Old With Fitzpatrick Type I, II, III And IV Skin To UV-Radiation From Artificial Light Sources

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Skin Cancer
Drug Information available for: Celecoxib
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Fitzpatrick type I-IV skin
  • No history of photosensitivity (e.g., systemic or discoid lupus erythematosus, polymorphous light eruption, or photocontact dermatitis)
  • No history of abnormal tanning responses or other unusual reactions to natural or artificial light sources
  • Willing to wear sun-protective clothing and SPF 15-49 sunscreen
  • Willing and able to restrict the frequency of high ultraviolet-exposure activities (e.g., exposure to sunlight, tanning boxes, or other artificial light sources)
  • No history of keloid formation



  • 20 to 60

Performance status:

  • Not specified

Life expectancy:

  • Not specified


  • WBC ≥ 3,500/mm^3
  • Hemoglobin ≥ 12.0 g/dL
  • No bleeding disorder


  • Bilirubin ≤ 20% above upper limit of normal (ULN)
  • AST and ALT ≤ 20% above ULN
  • No chronic or acute hepatic disease


  • Creatinine ≤ 20% above ULN
  • No chronic or acute renal disease


  • No active gastrointestinal disease (e.g., inflammatory bowel disease)
  • No pancreatic disease
  • No esophageal, gastric, pyloric channel, or duodenal ulceration


  • No invasive cancer except nonmelanoma skin cancer cured by excision or stage I cervical cancer
  • No hypersensitivity or adverse reactions to NSAIDs, salicylates, cyclo-oxygenase-2 (COX-2) inhibitors, or sulfonamides
  • No condition that would preclude the use of NSAIDs
  • No clinically significant laboratory abnormalities
  • No medical or psychosocial condition that would preclude study participation
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile participants must use effective contraception


Biologic therapy:

  • No concurrent chemo-immunotherapy


  • See Biologic therapy
  • At least 1 year since prior chemotherapy, including topical fluorouracil

Endocrine therapy:

  • At least 2 weeks since prior topical glucocorticoids
  • At least 30 days since prior systemic corticosteroids
  • No concurrent systemic glucocorticoids (inhaled corticosteroids allowed)
  • No concurrent topical corticosteroids
  • No concurrent hormonal therapy
  • Hormone replacement (e.g., estrogen or thyroid replacement) allowed


  • No concurrent radiotherapy


  • Not specified


  • At least 14 days since prior aspirin (> 100 mg/day) or other non-steroidal anti-inflammatory drugs (NSAIDs) taken at least 3 times per week
  • At least 2 weeks since prior topical alpha hydroxy acids (e.g., glycolic acid or lactic acid)
  • At least 6 months since prior oral retinoids (3 months for topical retinoids to the face)
  • At least 30 days since prior treatment for esophageal, gastric, pyloric channel, or duodenal ulceration
  • At least 30 days since prior investigational medication
  • No other concurrent investigational medication
  • No concurrent topical vitamin A derivatives and/or alpha hydroxy acids
  • No concurrent immunosuppressive drugs
  • No concurrent topical medication to the skin, including prescription and over-the-counter preparations (moisturizers and emollients allowed)
  • No concurrent lithium, fluconazole, or warfarin
  • No concurrent chronic NSAIDs (> 3 times per week for > 2 consecutive weeks per year)
  • Concurrent cardioprotective doses of aspirin (≤ 100 mg/day) allowed
  • Concurrent acetaminophen allowed
  • No concurrent green tea consumption of > 2 cups per day

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00025051

United States, New York
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
National Cancer Institute (NCI)
Study Chair: David R. Bickers, MD Herbert Irving Comprehensive Cancer Center Identifier: NCT00025051     History of Changes
Other Study ID Numbers: CDR0000068840
First Posted: January 27, 2003    Key Record Dates
Last Update Posted: March 22, 2013
Last Verified: December 2006

Keywords provided by National Cancer Institute (NCI):
basal cell carcinoma of the skin
squamous cell carcinoma of the skin

Additional relevant MeSH terms:
Skin Neoplasms
Neoplasms by Site
Skin Diseases
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents