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EEG and EMG Analysis of Ideomotor Apraxia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00024999
Recruitment Status : Completed
First Posted : October 11, 2001
Last Update Posted : March 4, 2008
Information provided by:
National Institutes of Health Clinical Center (CC)

Brief Summary:

This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease. It will use electroencephalography (EEG) and electromyography (EMG) to compare brain function in normal subjects and in patients with-a disorder affecting patients with stroke and other brain lesions. These patients have problems with timing, sequence and spatial organization of certain types of movements.

EEG measures the electrical activity of the brain. The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head. EMG measures electrical activity from muscles. It uses wire electrodes placed on the skin over the muscles.

Adult healthy normal volunteers and patients with ideomotor apraxia with a single left brain lesion may be eligible for this study.

Study participants will be asked to make certain movements with their arms or hands, such as waving and using scissors. Brain and muscle activity will be measured during these tasks with EEG and EMG recordings. Patients may be asked to repeat these tests over time as their condition changes (such as during recovery from a stroke) to gain information about the recovery process.

Condition or disease
Ideomotor Apraxia

Detailed Description:

Ideomotor apraxia is a disorder affecting patients with stroke and a variety of other brain lesions. The disorder involves problematic timing, sequence, and spatial organization of gestured movements. As a result, patients suffer from incorrect temporal and spatial components to movements as evidenced during pantomime of transitive and intransitive movements. The errors can be seen in left and right hemisphere damaged patients during intransitive movements, but lesions predominate in the left hemisphere for inability to pantomime transitive movements. Thus far, damage to parietofrontal circuits has been implicated in significantly contributing to this disorder. These circuits, which pave the way for sensorimotor processing, are of clear interest in the nature of praxis.

In the present study, we plan to evaluate further the parietofrontal circuits in these patients. Using EEG, we will analyze the movement related cortical potentials (MRCP) in these patients compared to controls to evaluate any cortical planning differences. We will analyze how the circuits play a role in transitive and intransitive movements in normal subjects and patients with Ideomotor apraxia. Each patient will make a series of movement during 64 channel EEG and EMG recordings. Following recordings, analysis will be made of the event related desynchronization (ERD) and the MRCP. Further analysis will look at the activation of the parietofrontal circuitry in patients using correlation and coherence methods. For the same purposes, MEG studies will be performed to assess similar measures.

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Study Type : Observational
Enrollment : 60 participants
Official Title: EEG Analysis of Ideomotor Apraxia
Study Start Date : October 2001
Study Completion Date : September 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

We will study normal volunteers and patient groups between the ages of 18-80 years of age within the following parameters:


Normal subjects.

Patients diagnosed with Ideomotor apraxia with a single left hemisphere lesion.

Patients with Ideomotor apraxia with corticobasal ganglionic degeneration.


Normal subjects: abnormal neurologic examination or history of neurologic disorders.

Ideomotor apraxic patients: a second neurologic disorder including more than one brain lesion or the inability to cooperate fully.

Normal and Ideomotor apraxic patients: cognitively impaired subjects will not be accrued (for the purposes of this study, patients that can provide full informed consent for the study are not considered cognitively impaired).

For MRI studies, patients with metallic implants to remove potential risks from this procedure.

For MRI purposes, women who are pregnant are excluded from this part of the protocol. Therefore, all women of childbearing potential will have a pregnancy test performed, which must be negative, before proceeding.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00024999

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United States, Maryland
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Layout table for additonal information Identifier: NCT00024999    
Other Study ID Numbers: 020011
First Posted: October 11, 2001    Key Record Dates
Last Update Posted: March 4, 2008
Last Verified: September 2005
Keywords provided by National Institutes of Health Clinical Center (CC):
Parietofrontal Circuitry
Ideomotor Apraxia
Healthy Volunteer
Normal Control
Additional relevant MeSH terms:
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Apraxia, Ideomotor
Psychomotor Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases