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Collaborative Study of 1,3 Butadiene Biomarkers

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00023140
First Posted: August 24, 2001
Last Update Posted: April 14, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.

Condition
Cancer

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Collaborative Study of 1,3 Butadiene Biomarkers

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 80
Study Start Date: July 1999
Study Completion Date: June 2002
Primary Completion Date: May 2002 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   19 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
Healthy adults without metabolic disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00023140


Locations
United States, Massachusetts
Harvard School of Public Health
Boston, Massachusetts, United States, 02115
Taiwan
National Chung Kung University
Tainan, Taiwan
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

ClinicalTrials.gov Identifier: NCT00023140     History of Changes
Other Study ID Numbers: 9401-CP-001
First Submitted: August 22, 2001
First Posted: August 24, 2001
Last Update Posted: April 14, 2015
Last Verified: April 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
biomarkers
exposure
adducts
metabolites
butadiene