Collaborative Study of 1,3 Butadiene Biomarkers

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: August 22, 2001
Last updated: March 22, 2006
Last verified: March 2006

Butadiene is a suspect human carcinogen to which most people are exposed daily. Exposures are difficult to measure by air sampling. This study examines the relationship between air levels and several biomarkers of exposure. Biomarkers are substances analyzed in human tissues or waste products. Adducts are materials formed when a chemical reacts with a biological material. In this study we are looking at biomarkers in the blood: hemoglobin and DNA adducts, and urinary metabolites. If a strong relationship is found then the amounts of biomarkers in a person's blood or urine can tell us how much they have been exposed. The tests are being conducted on petrochemical workers who have a wide range of exposures to butadiene. An international group of investigators is conducting the study.


Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 80
Study Start Date: July 1999
Estimated Study Completion Date: December 2002

Ages Eligible for Study:   19 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Healthy adults without metabolic disorders

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00023140

United States, Massachusetts
Harvard School of Public Health
Boston, Massachusetts, United States, 02115
National Chung Kung University
Tainan, Taiwan
Sponsors and Collaborators
  More Information

No publications provided Identifier: NCT00023140     History of Changes
Other Study ID Numbers: 9401-CP-001
Study First Received: August 22, 2001
Last Updated: March 22, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
butadiene processed this record on March 30, 2015