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p450 Mediated Lung Toxicity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00023114
Recruitment Status : Completed
First Posted : August 24, 2001
Last Update Posted : September 4, 2006
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity. All of the toxicants in question are encountered by humans in the workplace, through lifestyle choices (cigarette smoking) and as a result of environmental contamination. The high incidence of pulmonary diseases in the human population means that it will be difficult if not impossible to determine whether humans are at risk from exposure to these chemicals without solid mechanistic data. Recent rodent bioassays suggest that these compounds have oncogenic potential further supporting the need to test the potential for injury in primates. As part of this testing, we intend to establish in vitro methods for assessing critical steps in the metabolism of these agents and their interaction with cellular macromolecules. Once this is done, similar studies can be conducted in Rhesus or in human lung tissue that is available because it cannot be used for transplant purposes.

Condition or disease
Pulmonary Disease

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Study Type : Observational
Enrollment : 10 participants
Study Start Date : September 2000
Study Completion Date : September 2001

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
All available organ donors in the Sacramento area
Layout table for additonal information Identifier: NCT00023114    
Other Study ID Numbers: 8408-CP-001
First Posted: August 24, 2001    Key Record Dates
Last Update Posted: September 4, 2006
Last Verified: September 2006
Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
lung function
Additional relevant MeSH terms:
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Lung Diseases
Respiratory Tract Diseases