p450 Mediated Lung Toxicity

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
First received: August 22, 2001
Last updated: September 1, 2006
Last verified: September 2006
The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity. All of the toxicants in question are encountered by humans in the workplace, through lifestyle choices (cigarette smoking) and as a result of environmental contamination. The high incidence of pulmonary diseases in the human population means that it will be difficult if not impossible to determine whether humans are at risk from exposure to these chemicals without solid mechanistic data. Recent rodent bioassays suggest that these compounds have oncogenic potential further supporting the need to test the potential for injury in primates. As part of this testing, we intend to establish in vitro methods for assessing critical steps in the metabolism of these agents and their interaction with cellular macromolecules. Once this is done, similar studies can be conducted in Rhesus or in human lung tissue that is available because it cannot be used for transplant purposes.

Pulmonary Disease

Study Type: Observational
Study Design: Allocation: Random Sample
Primary Purpose: Screening

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 10
Study Start Date: September 2000
Estimated Study Completion Date: September 2001

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
All available organ donors in the Sacramento area
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

ClinicalTrials.gov Identifier: NCT00023114     History of Changes
Other Study ID Numbers: 8408-CP-001 
Study First Received: August 22, 2001
Last Updated: September 1, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
lung function

ClinicalTrials.gov processed this record on May 02, 2016