Genetic Analysis of Hereditary Disorders of Hearing and Balance
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00023049|
Recruitment Status : Recruiting
First Posted : August 22, 2001
Last Update Posted : December 17, 2018
This study will try to identify the genetic causes of hereditary hearing loss or balance disorders.
People with a hearing or balance disorder that affects more than one family member may be eligible for this study. They and their immediate family members may undergo some or all of the following procedures:
- Medical and family history, including questions about hearing, balance and other ear-related issues, and review of medical records.
- Routine physical examination.
- Blood draw or buccal swab (brushing inside the cheek to collect cells) Tissue is collected for DNA analysis to look for changes in genes that may be related to hearing loss.
- Hearing tests The subject listens for tones emitted through a small earphone.
- Balance tests to see if balance functions of the inner ear are associated with the hearing loss In one test the subject wears goggles and watches moving lights while cold or warm air is blown into the ears. A second test involves sitting in a spinning chair in a quiet, dark room.
- Photograph A photograph may be taken as a record of eye shape and color, distance between the eyes, and hair color.
- Computed tomography (CT) and magnetic resonance imaging (MRI) scans These tests show the structure of the inner ear. For CT, the subject lies still for a short time while X-ray images are obtained. For MRI, the patient lies on a stretcher that is moved into a cylindrical machine with a strong magnetic field. The magnetic field and radio waves produce images of the inner ear. The radio waves cause loud thumping noises that can be muffled by the use of earplugs.
|Condition or disease|
|Sensorineural Hearing Loss Hearing Disorder Vestibular Disease|
|Study Type :||Observational|
|Estimated Enrollment :||750 participants|
|Official Title:||Genetic Analysis of Hereditary Disorders of Hearing and Balance|
|Study Start Date :||August 20, 2001|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00023049
|Contact: Andrew J Griffith, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Institute of Child Health, College of Medicine, University of Ibadan||Recruiting|
|Contact: Andrew Griffith, M.D. (301) 496-1960 email@example.com|
|Principal Investigator:||Andrew J Griffith, M.D.||National Institute on Deafness and Other Communication Disorders (NIDCD)|