Genetic Analysis of Hereditary Disorders of Hearing and Balance
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Purpose
This study will try to identify the genetic causes of hereditary hearing loss or balance disorders.
People with a hearing or balance disorder that affects more than one family member may be eligible for this study. They and their immediate family members may undergo some or all of the following procedures:
- Medical and family history, including questions about hearing, balance and other ear-related issues, and review of medical records.
- Routine physical examination.
- Blood draw or buccal swab (brushing inside the cheek to collect cells) Tissue is collected for DNA analysis to look for changes in genes that may be related to hearing loss.
- Hearing tests The subject listens for tones emitted through a small earphone.
- Balance tests to see if balance functions of the inner ear are associated with the hearing loss In one test the subject wears goggles and watches moving lights while cold or warm air is blown into the ears. A second test involves sitting in a spinning chair in a quiet, dark room.
- Photograph A photograph may be taken as a record of eye shape and color, distance between the eyes, and hair color.
- Computed tomography (CT) and magnetic resonance imaging (MRI) scans These tests show the structure of the inner ear. For CT, the subject lies still for a short time while X-ray images are obtained. For MRI, the patient lies on a stretcher that is moved into a cylindrical machine with a strong magnetic field. The magnetic field and radio waves produce images of the inner ear. The radio waves cause loud thumping noises that can be muffled by the use of earplugs.
| Condition |
|---|
|
Sensorineural Hearing Loss Hearing Disorder Vestibular Disease |
| Study Type: | Observational |
| Official Title: | Genetic Analysis of Hereditary Disorders of Hearing and Balance |
| Estimated Enrollment: | 750 |
| Study Start Date: | August 2001 |
Hereditary hearing impairment is a genetically heterogeneous disorder that can be caused by mutations in any one of hundreds of different genes. Approximately 20 genes have now been identified in which mutations can cause nonsyndromic sensorineural hearing loss. The identification and analysis of these genes and their mutations are providing critical insights into the development, structure, and function of the auditory system, as well as the molecular mechanisms associated with disruption of these processes. In contrast, the molecular mechanisms underlying familial disorders affecting peripheral vestibular function appear to be more rare, have not been well described, and are less well understood. The peripheral auditory and vestibular systems share many common features in both health and disease, and many hereditary hearing loss disorders also affect vestibular function. The purpose of this study is to identify genes and mutations causing hereditary disorders of hearing, balance, or both. Members of families segregating hereditary disorders of hearing or balance will be enrolled in the proposed study in order to: (1) define and characterize the phenotypes and natural histories; (2) identify the underlying causative mutations and genes by linkage, positional cloning, and/or candidate gene mutation analyses; (3) and correlate observed phenotypes with the corresponding mutations and functions of the underlying genes.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
- INCLUSION CRITERIA:
Persons with known SNHL and/or peripheral vestibular dysfunctions caused by genetic etiology
Family members of persons with known SNHL and/or peripheral vestibular dysfunction caused by genetic etiology
Adults must be able to provide informed consent
Minors must have a parent or guardian able to provide informed consent
Subjects must be 0-99 years of age
For Nigeria subjects with non-syndromic hearing loss, their hearing loss must be early-onset, before 10 years of age, to be eligible.
EXCLUSION CRITERIA:
Persons with SNHL and/or peripheral vestibular dysfunction caused by a nongenetic etiology such as trauma, infection, metabolic or immunologic disorders, or exposure to ototoxic agents such as noise or aminoglycoside antibiotics will not be included in this protocol.
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00023049
| Contact: Julie Muskett | (301) 435-1574 | muskettj@mail.nih.gov | |
| Contact: Andrew J Griffith, M.D. | (301) 402-2829 | griffita@mail.nih.gov |
| United States, Maryland | |
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
| Bethesda, Maryland, United States, 20892 | |
| Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 prpl@mail.cc.nih.gov | |
| Nigeria | |
| Institute of Child Health, College of Medicine, University of Ibadan | Recruiting |
| Ibadan, Nigeria | |
| Contact: Andrew Griffith, M.D. (301) 496-1960 griffita@mail.nih.gov | |
| Principal Investigator: | Andrew J Griffith, M.D. | National Institute on Deafness and Other Communication Disorders (NIDCD) |
More Information
Additional Information:
Publications:
| Responsible Party: | National Institutes of Health Clinical Center (CC) ( National Institute on Deafness and Other Communication Disorders (NIDCD) ) |
| ClinicalTrials.gov Identifier: | NCT00023049 History of Changes |
| Other Study ID Numbers: | 010229, 01-DC-0229 |
| Study First Received: | August 21, 2001 |
| Last Updated: | November 11, 2014 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Deafness Genes Impairment Auditory Vestibular |
Hereditary Hearing Disorder Hearing Impairment Sensorineural Hearing Loss Vestibular Dysfunction SNHL |
Additional relevant MeSH terms:
|
Vestibular Diseases Hearing Disorders Hearing Loss, Sensorineural Ear Diseases Hearing Loss Labyrinth Diseases |
Nervous System Diseases Neurologic Manifestations Otorhinolaryngologic Diseases Sensation Disorders Signs and Symptoms |
ClinicalTrials.gov processed this record on March 03, 2015