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Prevalence of Sleep-Disordered Breathing in Children

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Edward Bixler, Milton S. Hershey Medical Center Identifier:
First received: August 14, 2001
Last updated: March 12, 2014
Last verified: March 2014
To investigate the prevalence and clinical significance of sleep-disordered breathing (SDB) in children.

Lung Diseases Sleep Apnea Syndromes

Study Type: Observational
Study Design: Observational Model: Cohort
Official Title: Prevalence of Sleep Disordered Breathing in Children

Further study details as provided by Edward Bixler, Milton S. Hershey Medical Center:

Enrollment: 700
Study Start Date: August 2001
Study Completion Date: November 2006
Primary Completion Date: June 2006 (Final data collection date for primary outcome measure)
Detailed Description:


SDB in children appears to be a common condition, affecting approximately 1 to 3 percent of children. Many aspects of childhood SDB remain understudied and poorly understood, including its precise prevalence, the optimal means of identifying children who should undergo polysomnography, and the potentially major impact of this condition on health, cognitive development, and behavior.


The population-based, cross-sectional study of 6- to 16-year-old schoolchildren in Dauphin County, Pennsylvania is a two-part study. In the first part of the study, parents of every child enrolled in local elementary schools will complete a questionnaire that will assess general sleep, behavior, and learning problems. In the second part of the study, 1,000 children will be randomly selected based on their risk for SDB, as determined by the questionnaire. They will be evaluated in a sleep laboratory to determine the presence of SDB. A thorough pediatric ear, nose, throat, and pulmonary evaluation will be conducted; school records and behavior will also be assessed. The parents of the children will be interviewed, and information will be collected on the family history of risk factors associated with childhood SDB. This strategy will be beneficial in establishing the prevalence and clinical significance of SDB in children.


Ages Eligible for Study:   5 Years to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Random representative population sample of children in elementary school (K-5)

Inclusion Criteria:

  • Phase I: Sampled all children by questionnaire completed by parent or guardian in three school districts in Dauphin County, Pennsylvania
  • Phase II: Recruited a representative sample of 700 to complete a more detailed analysis in the laboratory
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Please refer to this study by its identifier: NCT00022789

United States, Pennsylvania
Pennsylvania State University Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Sponsors and Collaborators
Milton S. Hershey Medical Center
National Heart, Lung, and Blood Institute (NHLBI)
Study Chair: Edward O. Bixler, PhD Milton S. Hershey Medical Center
  More Information

Responsible Party: Edward Bixler, Professor, Vice Chair Research, Milton S. Hershey Medical Center Identifier: NCT00022789     History of Changes
Other Study ID Numbers: 980
R01HL063772 ( U.S. NIH Grant/Contract )
Study First Received: August 14, 2001
Last Updated: March 12, 2014

Keywords provided by Edward Bixler, Milton S. Hershey Medical Center:
Sleep-Disordered Breathing

Additional relevant MeSH terms:
Lung Diseases
Respiratory Aspiration
Sleep Apnea Syndromes
Respiratory Tract Diseases
Respiration Disorders
Pathologic Processes
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on September 21, 2017