Factors Affecting Weight Gain in Women Receiving Adjuvant Chemotherapy for Breast Cancer
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|ClinicalTrials.gov Identifier: NCT00019643|
Recruitment Status : Terminated
First Posted : March 6, 2007
Last Update Posted : March 29, 2012
RATIONALE: Chemotherapy may affect various factors that can lead to weight gain.
PURPOSE: Clinical trial to evaluate factors that may affect weight gain in women receiving adjuvant chemotherapy for stage I, stage II, or stage IIIA breast cancer.
|Condition or disease|
|Depression Stage I Breast Cancer Stage IIIA Breast Cancer Nutrition Stage II Breast Cancer Psychosocial Effects/Treatment Quality of Life|
OBJECTIVES: I. Evaluate the relative contributions of factors that may lead to weight gain in breast cancer patients receiving adjuvant chemotherapy. Factors examined include: Hormonal and growth factor status (follicle stimulating hormone, total, bound, and free estradiol, androgens, sex hormone binding globulin, thyroid hormones, prolactin, insulin-like growth factors I and II, and plasma leptin) Factors affecting energy intake or expenditure (oral intake, physical activity, and resting metabolic rate) Psychological factors (depression and quality of life) II. Evaluate the effect of chemotherapy on hormonal and growth factor status in these patients.
III. Assess the impact of chemotherapy on bone marrow density in these patients.
Data is collected from women diagnosed with primary breast cancer at 3 points (5 visits): (i) after breast cancer surgery, but before chemotherapy begins (2 visits to NIH day hospital 1 week apart); (ii) 2-3 weeks after chemotherapy has ended (2 visits, 1 week apart); and (iii) 6 months after chemotherapy has ended (1 visit). Tests conducted during these visits include evaluation of blood for hormones, growth factors, and leptin; body composition by DXA; visceral and subcutaneous abdominal adipose tissue by an axial CT scan; and evaluation of resting metabolic rate and daily energy expenditure by a single administration of doubly labeled water at visits "a" and "b" during data collection timepoints 1 and 2. Questionnaires assessing epidemiologic risk factors for breast cancer, dietary intake, physical activity, depression, and quality of life are also administered at the three timepoints.
A total of 140 patients will be accrued for this study within 1-2 years.
|Study Type :||Observational|
|Actual Enrollment :||26 participants|
|Official Title:||Prospective Study of Potential Factors Affecting Weight in Breast Cancer Patients Receiving Adjuvant Chemotherapy|
|Study Start Date :||August 1999|
|Actual Study Completion Date :||April 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00019643
|United States, Maryland|
|Cancer Prevention Studies Branch|
|Bethesda, Maryland, United States, 20892|
|Study Chair:||Noreen Aziz||National Cancer Institute (NCI)|