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Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

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ClinicalTrials.gov Identifier: NCT00018785
Recruitment Status : Completed
First Posted : July 5, 2001
Last Update Posted : January 21, 2009
Sponsor:
Information provided by:
VA Office of Research and Development

Brief Summary:
Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.

Condition or disease Intervention/treatment Phase
Kidney Disease Procedure: donor bone marrow infusion Not Applicable

Study Type : Interventional  (Clinical Trial)
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants
Study Start Date : October 1998
Study Completion Date : September 2003

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
Living related donor kidney transplant recipients and the living related donors.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00018785


Locations
United States, Florida
VAMC Miami
Miami, Florida, United States, 33125
Sponsors and Collaborators
VA Office of Research and Development
Investigators
OverallOfficial: Camillo Ricordi, M.D.
OverallOfficial: Andreas Tzakis, M.D.
OverallOfficial: Violet Esquenazi, Ph.D.
OverallOfficial: Keith Zucker, Ph.D.

ClinicalTrials.gov Identifier: NCT00018785     History of Changes
Other Study ID Numbers: IMMU-035-98S
First Posted: July 5, 2001    Key Record Dates
Last Update Posted: January 21, 2009
Last Verified: December 2004

Keywords provided by VA Office of Research and Development:
kidney transplantation
immunosuppression
bone marrow

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases