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Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

This study has been completed.
Information provided by:
VA Office of Research and Development Identifier:
First received: July 3, 2001
Last updated: January 20, 2009
Last verified: December 2004
Diabetes and end-stage kidney, liver and heart disease are prominent health issues among veteran patients. Successful solid organ transplantation in the absence of chronic immunosuppressive therapy (specific acquired immunological tolerance) is a desirable therapeutic option. This project extends recent observations supporting the use of concommitant donor bone marrow cell infusion as a means of modulating the immune response in kidney transplantation, thereby allowing a substantial decrease or withdrawal of potentially toxic immunosuppressive drugs.

Condition Intervention
Kidney Disease
Procedure: donor bone marrow infusion

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Living-Related Donor Bone Marrow Immunoregulation in Kidney Transplants

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Study Start Date: October 1998
Estimated Study Completion Date: September 2003

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Living related donor kidney transplant recipients and the living related donors.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00018785

United States, Florida
VAMC Miami
Miami, Florida, United States, 33125
Sponsors and Collaborators
VA Office of Research and Development
OverallOfficial: Camillo Ricordi, M.D.
OverallOfficial: Andreas Tzakis, M.D.
OverallOfficial: Violet Esquenazi, Ph.D.
OverallOfficial: Keith Zucker, Ph.D.
  More Information Identifier: NCT00018785     History of Changes
Other Study ID Numbers: IMMU-035-98S
Study First Received: July 3, 2001
Last Updated: January 20, 2009

Keywords provided by VA Office of Research and Development:
kidney transplantation
bone marrow

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases processed this record on May 25, 2017