Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients
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ClinicalTrials.gov Identifier: NCT00018759 |
Recruitment Status :
Completed
First Posted : July 5, 2001
Last Update Posted : January 21, 2009
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Depression Hypertension | Drug: paroxetine Behavioral: ongoing psychological screening | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double |
Primary Purpose: | Treatment |
Official Title: | Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients |
Study Start Date : | March 2001 |
Study Completion Date : | October 2003 |


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Ages Eligible for Study: | 25 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Subjects for all study groups will be male and between the ages of 25 and 65
Hypertension & Depression Group: Hypertension controlled with an ACE-inhibitor anti-hypertensive; no co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; depression as diagnosed by structured interview and HDRS score of 18; no active participation in another clinical trial; no current suicidal/ homicidal ideation
Hypertension Group: Hypertension controlled with an ACE-inhibitor anti-hypertensive; no co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; no active participation in another clinical trial; no current suicidal/ homicidal ideation
Depression Group: No co-morbid medical conditions known to influence psychological functioning or platelet calcium responses including uncontrolled diabetes, MI or CVA within 6 months of enrollment, secondary hypertension; depression as diagnosed by structured interview and HDRS score of 18; no active participation in another clinical trial; no current suicidal/ homicidal ideation

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00018759
United States, Illinois | |
Edward Hines Jr. Hospital | |
Hines, Illinois, United States, 60141 |
ClinicalTrials.gov Identifier: | NCT00018759 |
Other Study ID Numbers: |
MHBS-023-00S |
First Posted: | July 5, 2001 Key Record Dates |
Last Update Posted: | January 21, 2009 |
Last Verified: | December 2004 |
Serotonin, Hypertension, Depression |
Hypertension Depression Vascular Diseases Cardiovascular Diseases Behavioral Symptoms Paroxetine Serotonin Uptake Inhibitors Neurotransmitter Uptake Inhibitors Membrane Transport Modulators Molecular Mechanisms of Pharmacological Action |
Neurotransmitter Agents Serotonin Agents Physiological Effects of Drugs Antidepressive Agents, Second-Generation Antidepressive Agents Psychotropic Drugs Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors |