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Biological Aspects of Depression and Antidepressant Drugs

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00018733
First Posted: July 5, 2001
Last Update Posted: January 21, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
VA Office of Research and Development
  Purpose
This study will be measuring changes in depressive symptoms over a 7 week time period. Double-blind placebo controlled trial using the pharmacologic agents Paroxetine or Desipramine.

Condition Intervention
Depression Drug: paroxetine Drug: Desipramine

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Official Title: Biological Aspects of Depression and Antidepressant Drugs

Resource links provided by NLM:


Further study details as provided by VA Office of Research and Development:

Study Start Date: September 1996
Estimated Study Completion Date: December 2001
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   21 Years to 69 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • Diagnosis of major depressive disorder Ham-D Score > 18
  • English speaking with ability to read and sign an informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00018733


Locations
United States, Texas
South Texas Veterans Health Care System
San Antonio, Texas, United States, 78229
Sponsors and Collaborators
VA Office of Research and Development
Investigators
OverallOfficial: Steve Brannan, M.D.
OverallOfficial: Cheryl Gonzalez, M.D.
  More Information

ClinicalTrials.gov Identifier: NCT00018733     History of Changes
Other Study ID Numbers: MHBS-031-99F
First Submitted: July 3, 2001
First Posted: July 5, 2001
Last Update Posted: January 21, 2009
Last Verified: December 2004

Keywords provided by VA Office of Research and Development:
Depression

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Antidepressive Agents
Paroxetine
Desipramine
Psychotropic Drugs
Serotonin Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Serotonin Agents
Physiological Effects of Drugs
Antidepressive Agents, Second-Generation
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Antidepressive Agents, Tricyclic
Adrenergic Uptake Inhibitors
Adrenergic Agents