Regulation of Sterol Homeostasis
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|ClinicalTrials.gov Identifier: NCT00018720|
Recruitment Status : Completed
First Posted : July 5, 2001
Last Update Posted : January 21, 2009
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.
This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.
|Condition or disease|
|Study Type :||Observational|
|Official Title:||Regulation of Sterol Homeostasis|
|Study Start Date :||April 1996|
|Estimated Study Completion Date :||December 2000|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00018720
|United States, Minnesota|
|VA Medical Center|
|Minneapolis, Minnesota, United States, 55417|
|OverallOfficial:||Norman Javitt, M.D.|
|OverallOfficial:||Alan Hofmann, M.D.|
|OverallOfficial:||Loren Zech, M.D.|