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Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly

This study has been completed.
Information provided by:
VA Office of Research and Development Identifier:
First received: July 3, 2001
Last updated: June 22, 2011
Last verified: June 2011
This study's primary objective is to determine the independent and combined effects of progressive resistance muscle strength training and testosterone on the development of sustainable improvements in physical function.

Condition Intervention Phase
Muscle Weakness
Muscular Atrophy
Procedure: exercise
Drug: testosterone
Phase 4

Study Type: Interventional
Official Title: Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Estimated Enrollment: 88
Study Start Date: January 1999
Study Completion Date: August 2006
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
1 Procedure: exercise Drug: testosterone


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

The study will be limited to those patients who are metabolically stable and free of metastatic cancer and limiting end organ disease. Their total serum testosterone must be less than 480 and PSA less than 10.

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT00018356

United States, Arkansas
Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock
No. Little Rock, Arkansas, United States, 72114-1706
Sponsors and Collaborators
VA Office of Research and Development
Principal Investigator: Dennis Sullivan, MD Central Arkansas VHS Eugene J. Towbin Healthcare Ctr, Little Rock
  More Information

Responsible Party: Sullivan, Dennis - Principal Investigator, Department of Veterans Affairs Identifier: NCT00018356     History of Changes
Other Study ID Numbers: AGCG-007-98S
Study First Received: July 3, 2001
Last Updated: June 22, 2011

Keywords provided by VA Office of Research and Development:

Additional relevant MeSH terms:
Muscular Atrophy
Muscle Weakness
Pathological Conditions, Anatomical
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Muscular Diseases
Musculoskeletal Diseases
Pathologic Processes
Testosterone enanthate
Testosterone undecanoate
Testosterone 17 beta-cypionate
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Anabolic Agents processed this record on May 25, 2017