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Mechanisms Linking Depression to Cardiovascular Risk

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Viola Vaccarino MD/PhD, Emory University Identifier:
First received: June 15, 2001
Last updated: May 28, 2014
Last verified: May 2014
To examine the role of depression on risk for cardiovascular disease in twins.

Depression Cardiovascular Diseases Heart Diseases

Study Type: Observational

Further study details as provided by Viola Vaccarino MD/PhD, Emory University:

Study Start Date: June 2001
Study Completion Date: May 2006
Primary Completion Date: May 2006 (Final data collection date for primary outcome measure)
Detailed Description:


Multiple studies have demonstrated a higher risk of cardiovascular disease and worse cardiovascular disease (CVD) prognosis associated with depression that appear to synergistically and significantly adversely impact health. Because these initial studies are observational, much work remains to understand this area. If these conditions are mechanistically inter-related, identification of both conditions in the same subject may provide a means of enhancing risk stratification and most appropriately targeting therapy. If the interaction between the conditions is causal not simply associative, appropriate therapy interventions can be designed and tested.


The project is designed to clarify the role of depression on CVD risk by using a co-twin study design. The study will examine twin pairs from the Vietnam Era Twin Registry (VET). Twin pairs will be invited to participate if they meet two criteria: (1) neither has a history of CVD as of 1990 and (2) one twin is diagnosed with depression as of 1992. The study investigates the effects of depression on two indicators of "early" CVD: coronary flow reserve, assessed by means of Positron Emission Tomography (PET) myocardial infusion imaging; and heart rate variability (HRV) assessed by ambulatory electrocardiographic monitoring. It is hypothesized that within each pair, the twins who have clinical depression will exhibit lower coronary vascular reserve and lower heart rate variability compared with their co-twins without a history of depression. Moreover, by comparing the size of the intra-pair difference in these parameters between depression discordant monozygotic and dizygotic twins an estimate of the relative contributions of gene and environmental factors can be ascertained. In addition to the PET and HRV assessments, subjects will complete the Statistical Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV SCID) to document a history of depression, a psychometric battery including the Early Trauma Inventory and Hamilton Depression Scale, and such risk factors as cigarette smoking, physical activity, blood pressure and blood lipids, glucose and insulin, indices of inflammation and thrombogenicity including levels of reactive protein C, fibrinogen, and P-selectin, and neurohormones such as adrenocorticotropic hormone, cortisol, and dehydroepiandrosterone sulphate.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
  Contacts and Locations
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Please refer to this study by its identifier: NCT00017836

Sponsors and Collaborators
Emory University
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Viola Vaccarino Emory University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Viola Vaccarino MD/PhD, Professor And Chair, Emory University Identifier: NCT00017836     History of Changes
Other Study ID Numbers: IRB00024823
R01HL068630 ( U.S. NIH Grant/Contract )
970 ( Other Identifier: NIH ID )
Study First Received: June 15, 2001
Last Updated: May 28, 2014

Additional relevant MeSH terms:
Depressive Disorder
Cardiovascular Diseases
Heart Diseases
Behavioral Symptoms
Mood Disorders
Mental Disorders processed this record on August 17, 2017