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Hematotoxic Effects of Particulate Exposure

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ClinicalTrials.gov Identifier: NCT00015483
Recruitment Status : Completed
First Posted : April 23, 2001
Last Update Posted : September 4, 2006
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
Hematotoxicity is caused by a number of agents such as a benzene by-product called hydroquinone and the antitumor agent doxorubicin. This is a basic research study, conducted using normal human donors, of mechanisms involved in hematotoxicity and of the protective response of human hematopoietic progenitor cells to hematotoxic agents. Tumor necrosis factor exposure protects these cells from a subsequent exposure to hematotoxic agents. The alteration of gene expression in these cells caused by tumor necrosis factor is being studied. Additionally, the tumor necrosis factor-induced biochemical pathways involved in protection of human hematopoietic progenitor cells will be studied.

Condition or disease
Cancer

Study Type : Observational
Allocation: Random Sample
Official Title: Hematotoxic Effects of Benzene and Doxorubicin




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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • healthy
  • nonsmoking
  • no history of hematologic disorder
  • not pregnant
  • no medications which suppress hematopoiesis

ClinicalTrials.gov Identifier: NCT00015483     History of Changes
Other Study ID Numbers: 5020-CP-001
First Posted: April 23, 2001    Key Record Dates
Last Update Posted: September 4, 2006
Last Verified: September 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Hematotoxicity
Benzene
Bone Marrow