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Hematotoxic Effects of Particulate Exposure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00015483
First Posted: April 23, 2001
Last Update Posted: September 4, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
  Purpose
Hematotoxicity is caused by a number of agents such as a benzene by-product called hydroquinone and the antitumor agent doxorubicin. This is a basic research study, conducted using normal human donors, of mechanisms involved in hematotoxicity and of the protective response of human hematopoietic progenitor cells to hematotoxic agents. Tumor necrosis factor exposure protects these cells from a subsequent exposure to hematotoxic agents. The alteration of gene expression in these cells caused by tumor necrosis factor is being studied. Additionally, the tumor necrosis factor-induced biochemical pathways involved in protection of human hematopoietic progenitor cells will be studied.

Condition
Cancer

Study Type: Observational
Study Design: Allocation: Random Sample
Official Title: Hematotoxic Effects of Benzene and Doxorubicin

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria
  • healthy
  • nonsmoking
  • no history of hematologic disorder
  • not pregnant
  • no medications which suppress hematopoiesis
  Contacts and Locations
No Contacts or Locations Provided
  More Information

ClinicalTrials.gov Identifier: NCT00015483     History of Changes
Other Study ID Numbers: 5020-CP-001
First Submitted: April 20, 2001
First Posted: April 23, 2001
Last Update Posted: September 4, 2006
Last Verified: September 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Hematotoxicity
Benzene
Bone Marrow