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Prepulse Inhibition of Startle in Cocaine Dependence - 7

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00015249
First Posted: April 18, 2001
Last Update Posted: January 12, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
New York MDRU
Information provided by:
National Institute on Drug Abuse (NIDA)
  Purpose
The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

Condition Intervention Phase
Cocaine-Related Disorders Substance-Related Disorders Drug: Amantadine Phase 1

Study Type: Interventional
Study Design: Masking: Double
Primary Purpose: Diagnostic
Official Title: Prepulse Inhibition of Startle in Cocaine Dependence (Human)

Resource links provided by NLM:


Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:
  • Percent prepulse inhibition
  • Cocaine assessment

Estimated Enrollment: 0
Study Start Date: February 1997
Study Completion Date: May 1998
Primary Completion Date: April 1998 (Final data collection date for primary outcome measure)
Detailed Description:
The objective of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Cocaine dependence. Male. Right handed. Negative urine for cocaine

Exclusion Criteria:

Positive urine for cocaine. History of head trauma. Significant medical disease.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00015249


Locations
United States, New York
New York MDRU
New York, New York, United States, 10010
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
New York MDRU
Investigators
Principal Investigator: John Rotrosen, M.D. New York MDRU
  More Information

Publications:
CPDD, 98, 99 NIDA Research Monograph Series 179, 1998 Manuscript submitted..

ClinicalTrials.gov Identifier: NCT00015249     History of Changes
Other Study ID Numbers: NIDA-5-0013-7
Y01-5-0013-7
First Submitted: April 18, 2001
First Posted: April 18, 2001
Last Update Posted: January 12, 2017
Last Verified: June 1998

Keywords provided by National Institute on Drug Abuse (NIDA):
cocaine dependence

Additional relevant MeSH terms:
Disease
Cocaine-Related Disorders
Substance-Related Disorders
Pathologic Processes
Chemically-Induced Disorders
Mental Disorders
Cocaine
Amantadine
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
Antiparkinson Agents
Anti-Dyskinesia Agents
Antiviral Agents
Anti-Infective Agents
Analgesics, Non-Narcotic
Analgesics