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Dichloroacetate Kinetics, Metabolism and Toxicology

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00015015
Recruitment Status : Completed
First Posted : April 19, 2001
Last Update Posted : September 4, 2006
Information provided by:

Study Description
Brief Summary:
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Condition or disease Intervention/treatment
Lactic Acidosis Drug: Dichloroacetate

Study Design

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Study Start Date : December 1994
Estimated Study Completion Date : October 2002
Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Months to 65 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Children with congenital lactic acidosis Healthy adult volunteers
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00015015

United States, Florida
Univ. of Florida
Gainesville, Florida, United States, 32610
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
More Information

ClinicalTrials.gov Identifier: NCT00015015     History of Changes
Other Study ID Numbers: 7355-CP-001
First Posted: April 19, 2001    Key Record Dates
Last Update Posted: September 4, 2006
Last Verified: September 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Chlorinated hydrocarbons
Genetic disease

Additional relevant MeSH terms:
Acidosis, Lactic
Acid-Base Imbalance
Metabolic Diseases