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Dichloroacetate Kinetics, Metabolism and Toxicology

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: April 17, 2001
Last updated: September 1, 2006
Last verified: September 2006
Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Condition Intervention
Lactic Acidosis
Drug: Dichloroacetate

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 100
Study Start Date: December 1994
Estimated Study Completion Date: October 2002

Ages Eligible for Study:   3 Months to 65 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Children with congenital lactic acidosis Healthy adult volunteers
  Contacts and Locations
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Please refer to this study by its identifier: NCT00015015

United States, Florida
Univ. of Florida
Gainesville, Florida, United States, 32610
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information Identifier: NCT00015015     History of Changes
Other Study ID Numbers: 7355-CP-001
Study First Received: April 17, 2001
Last Updated: September 1, 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Chlorinated hydrocarbons
Genetic disease

Additional relevant MeSH terms:
Acidosis, Lactic
Acid-Base Imbalance
Metabolic Diseases processed this record on May 25, 2017