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Biomarkers of Benzene Exposure in Inner City Residents

This study has been completed.
Mickey Leland National Urban Air Toxics Research Center
Environmental Protection Agency (EPA)
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: April 16, 2001
Last updated: March 22, 2006
Last verified: March 2006
This study compares air pollution exposures of residents in a South Baltimore community next to major industry with those in a comparison community with much less industry nearby. Parents and children as well as adults alone will be included. Air levels of 3 chemicals that have been found in increased amounts in the community as well as two urinary breakdown products of benzene will be measured. Participants will limit the amount of sorbate preserved foods they eat as this preservative interferes with one of the benzene breakdown products. Benzene air and urine exposure measurements will be compared in each community as well as between communities. By including children and parents we will gather exposure information on children who may be more sensitive that adults to these types of pollution. Lastly, by restricting the amount of food preserved with sorbates, we can decide if this improves the use of ttMA for people exposed to benzene from air pollution.

Lung Disease Cancer

Study Type: Observational
Study Design: Allocation: Random Sample
Primary Purpose: Screening
Time Perspective: Cross-Sectional

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 90
Detailed Description:
The current study focuses on an environmental exposure assessment of a South Baltimore community residing near a heavily industrialized area. Exposure differences between this community and a reference community that is demographically similar to South Baltimore but has limited industrial impact will be assessed. Participants will include both parent child study pairs and adults. Outdoor, indoor and personal 72 hour badge monitoring for benzene, 1,3-butadiene and carbon tetrachloride will be performed. Two urinary biomarkers for benzene exposure, trans,trans-muconic acid (ttMA) and s-phenylmercapturic acid (S-PMA) will be measured at 3 daily time points over the 3 day period. Past work indicates that ingestion of sorbate preserved foods causes substantial interference with the benzene biomarker, ttMA. Therefore, participants will restrict their intake of sorbate preserved foods during the study. On the day of greatest dietary restriction, a 24 hour benzene personal air measurement will be obtained. Data analysis will include correlations of benzene badge exposure measurements and urinary biomarkers. Air and biomarker benzene exposure data will be compared between communities. Linear regression modeling will be used to determine important explanatory factors of the biomarkers. The inclusion of parent child study pairs will also allow correlation of benzene air levels and urinary biomarkers between parents and children. This will provide exposure information on a potentially susceptible subpopulation, e.g. children, and allow assessment of potential for age-related differences in benzene metabolism. Finally, we will be able to determine if dietary restriction is practical and results in greater specificity of ttMA as a benzene biomarker.

Ages Eligible for Study:   3 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
residence in one of the study communities
  Contacts and Locations
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Please refer to this study by its identifier: NCT00014963

United States, Maryland
Johns Hopkins University School of Hygiene and Public Health
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Mickey Leland National Urban Air Toxics Research Center
Environmental Protection Agency (EPA)
  More Information

Publications: Identifier: NCT00014963     History of Changes
Other Study ID Numbers: 7780-CP-001
Study First Received: April 16, 2001
Last Updated: March 22, 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
air pollution
muconic acid
phenylmercapturic acid

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases processed this record on September 19, 2017