Attention Deficit Disorder and Exposure to Lead

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00014898
Recruitment Status : Completed
First Posted : April 13, 2001
Last Update Posted : June 24, 2005
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)

Brief Summary:
We are examining the past exposure to lead in 250 well characterized children with ADHD, and a suitable group of controls. Our measure of past exposure is bone lead levels obtained by XRay fluorescence spectroscopy, a relatively new way of estimating bone lead concentrations, and by inference, body lead burdens. By comparing the lead concentrations in these two groups, controlling for other factors which could confound, we will estimate odds ratios for ADHD given elevated bone lead, and estimate the contribution of lead to this disease of childhood.

Condition or disease
Attention Deficit Disorder

Study Type : Observational
Enrollment : 500 participants
Observational Model: Case Control
Time Perspective: Retrospective
Study Start Date : June 1999
Study Completion Date : May 2002

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Ages Eligible for Study:   10 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Case subjects are drawn from adolescents aged 10 to 18 previously seen at Western Psychiatric Institute and Clinic for evaluation, and meet the DSM-IIIR criteria for diagnosis of ADHD based on a structured parent interview and standardized parent and teacher rating scales. Cases were also systematically observed and evaluated in the summer treatment program between 1987 and 1996 at WPIC. Controls are demographically matched non-ADHD adolescents, recruited from surrounding communities and pediatric practices.

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Please refer to this study by its identifier (NCT number): NCT00014898

United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS) Identifier: NCT00014898     History of Changes
Other Study ID Numbers: 5015-CP-001
First Posted: April 13, 2001    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: March 2001

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Lead exposure
Bone lead
Attention deficit

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Attention Deficit and Disruptive Behavior Disorders
Neurodevelopmental Disorders
Mental Disorders