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Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was:  Recruiting
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: March 6, 2001
Last updated: June 23, 2005
Last verified: December 2003
Hemodialysis remains associated with a high mortality (approximately 22% per year) and many complications despite improvements over the last twenty years. Several nephrologists have suggested that increasing the frequency and amount of dialysis will result in improved outcomes. In fact, various forms of daily dialysis have been performed in over 300 patients in the last 30 years with improvements in blood pressure, quality-of-life, bone disease, and other complications of renal failure. Whether this form of treatment can be expanded to the 220,000 Americans on hemodialysis is unknown. The primary outcome of this study is to determine the effectiveness of nocturnal dialysis in hemodialysis patients in St. Louis. If the pilot study is effective, then participation in a larger, multicenter trial is expected. The endpoints measured are use of antihypertensive medications, improvement in secondary hyperparathyroidism and use of phosphorus binders, quality-of-life measured by SF-36 surveys, and improvement in physical function as measured by maximal oxygen uptake.

Condition Intervention
Kidney Failure, Chronic Procedure: hemodialysis

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Primary Purpose: Treatment
Official Title: Comparison of Daily Nocturnal Hemodialysis With Daily Hemodialysis

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   21 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Adult patients with chronic renal failure requiring intermittent hemodialysis with a life expectancy of greater than 2 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT00012441

United States, Missouri
Washington University School of Medicine Recruiting
St. Louis, Missouri, United States, 63108
Contact: Brent W. Miller, M.D.    314-286-0801      
Principal Investigator: Brent W. Miller, M.D.         
Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information Identifier: NCT00012441     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0781
Study First Received: March 6, 2001
Last Updated: June 23, 2005

Keywords provided by National Center for Research Resources (NCRR):
Renal Dialysis

Additional relevant MeSH terms:
Renal Insufficiency
Kidney Failure, Chronic
Kidney Diseases
Urologic Diseases
Renal Insufficiency, Chronic processed this record on August 16, 2017