Genetic Analysis of Familial Brain Aneurysms
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|ClinicalTrials.gov Identifier: NCT00011856|
Recruitment Status : Completed
First Posted : March 2, 2001
Last Update Posted : March 4, 2008
This study will investigate cerebral (brain) aneurysms and their possible inheritance patterns in families. It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development.
People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study. They will undergo the following procedures:
- Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes that contribute to the development of brain aneurysms.
- A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain area where aneurysms typically occur. Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities.
If a more detailed picture of the brain is needed than can be obtained with MRA, a more specific MRA scan will be done using a contrast dye to enhance the images.
Patients may be invited to participate in related NIH research studies.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||Linkage Analysis of Familial Intracranial Aneurysms|
|Study Start Date :||February 2001|
|Estimated Study Completion Date :||March 2002|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00011856
|United States, Maryland|
|National Human Genome Research Institute (NHGRI)|
|Bethesda, Maryland, United States, 20892|