Genetic Analysis of Familial Brain Aneurysms
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
This study will investigate cerebral (brain) aneurysms and their possible inheritance patterns in families. It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development.
People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study. They will undergo the following procedures:
- Blood will be drawn (no more than 3 to 4 tablespoons) for research to identify genes that contribute to the development of brain aneurysms.
- A magnetic resonance angiograph (MRA) scan will be done to examine a specific brain area where aneurysms typically occur. Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities.
If a more detailed picture of the brain is needed than can be obtained with MRA, a more specific MRA scan will be done using a contrast dye to enhance the images.
Patients may be invited to participate in related NIH research studies.
| Condition |
|---|
|
Intracranial Aneurysm |
| Study Type: | Observational |
| Official Title: | Linkage Analysis of Familial Intracranial Aneurysms |
| Estimated Enrollment: | 300 |
| Study Start Date: | February 2001 |
| Estimated Study Completion Date: | March 2002 |
This study is designed to explore the genetics of familial cerebral aneurysms. Families in which more than one person has had a known cerebral aneurysm will be studied. Family histories will be obtained and participants identified who are willing to come to the NIH Clinical Center for an MRAngiograph and venipuncture. DNA will be isolated and linkage studies undertaken to identify loci involved in the etiology of familial cerebral aneurysms, using standard linkage approaches.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
INCLUSION CRITERIA:
Participants and their relatives that are affected or at a higher risk for cerebral aneurysms will be enrolled in this protocol.
EXCLUSION CRITERIA:
For the MR Angiograph portion of the study, any participant that is not able to sign the Clinical Center consent form due to metal implants, pregnancy, claustrophobia, or an allergy to gadolinium as a contrast will be excluded from the imaging part of the study.
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00011856
| United States, Maryland | |
| National Human Genome Research Institute (NHGRI) | |
| Bethesda, Maryland, United States, 20892 | |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00011856 History of Changes |
| Other Study ID Numbers: | 010101, 01-HG-0101 |
| Study First Received: | March 1, 2001 |
| Last Updated: | March 3, 2008 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Intracranial Aneurysms Cerebral Loci Susceptibility Genes |
Cerebral Aneurysm Familial Cerebral Aneurysm Genetics |
Additional relevant MeSH terms:
|
Aneurysm Intracranial Aneurysm Brain Diseases Cardiovascular Diseases Central Nervous System Diseases |
Cerebrovascular Disorders Intracranial Arterial Diseases Nervous System Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on March 02, 2015