Protection Against Benzene Toxicity

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: February 21, 2001
Last updated: June 23, 2005
Last verified: July 2002

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.

Aplastic Anemia

Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Prospective
Official Title: NQO1 in Protection Against Benzene Toxicity

Resource links provided by NLM:

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Study Start Date: July 1998
Estimated Study Completion Date: June 2001

Ages Eligible for Study:   21 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

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Please refer to this study by its identifier: NCT00011453

United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80262
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information

No publications provided Identifier: NCT00011453     History of Changes
Other Study ID Numbers: 9554-CP-001
Study First Received: February 21, 2001
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Aplastic anemia

Additional relevant MeSH terms:
Anemia, Aplastic
Bone Marrow Diseases
Hematologic Diseases processed this record on October 09, 2015